Natural γδT17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway

Natural IL-17-producing γδ T cells (γδT17 cells) are unconventional innate-like T cells that undergo functional programming in the fetal thymus. However, the intrinsic metabolic mechanisms of γδT17 cell development remain undefined. Here, we demonstrate that mTORC2, not mTORC1, selectively controls...

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Detalles Bibliográficos
Autores principales: Wang, Yunke, Qin, Hui, Cai, Yihua, Chen, Xu, Li, Hong, Montoya-Durango, Diego Elias, Ding, Chuanlin, Hu, Xiaoling, Chariker, Julia H., Sarojini, Harshini, Chien, Sufan, Rouchka, Eric C., Zhang, Huang-Ge, Zheng, Jie, Qiu, Fuming, Yan, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182300/
https://www.ncbi.nlm.nih.gov/pubmed/37192973
http://dx.doi.org/10.1016/j.isci.2023.106630

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