Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model

Extracellular protein disulfide isomerases (PDIs), including PDI, endoplasmic reticulum protein 57 (ERp57), ERp72, ERp46, and ERp5, are required for in vivo thrombus formation in mice. Platelets secrete PDIs upon activation, which regulate platelet aggregation. However, platelets secrete only ∼10% o...

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Detalles Bibliográficos
Autores principales: Lay, Angelina J., Dupuy, Alexander, Hagimola, Lejla, Tieng, Jessica, Larance, Mark, Zhang, Yunwei, Yang, Jean, Kong, Yvonne, Chiu, Joyce, Gray, Emilia, Qin, Zihao, Schmidt, Diana, Maclean, Jessica, Hofma, Benjamin, Ellis, Marc, Kalev-Zylinska, Maggie, Argon, Yair, Jackson, Shaun P., Hogg, Philip, Passam, Freda H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182305/
https://www.ncbi.nlm.nih.gov/pubmed/36508284
http://dx.doi.org/10.1182/bloodadvances.2022008457

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