Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells

Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a progressive increase in pulmonary artery pressure caused by pathological pulmonary artery remodeling. Here, we demonstrate that endothelial cell (EC) senescence plays a negative role in pulmonary hypertension via juxtacrine...

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Detalles Bibliográficos
Autores principales: Ramadhiani, Risa, Ikeda, Koji, Miyagawa, Kazuya, Ryanto, Gusty Rizky Tough, Tamada, Naoki, Suzuki, Yoko, Kirita, Yuhei, Matoba, Satoaki, Hirata, Ken-ichi, Emoto, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182325/
https://www.ncbi.nlm.nih.gov/pubmed/37192975
http://dx.doi.org/10.1016/j.isci.2023.106662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182325/
https://www.ncbi.nlm.nih.gov/pubmed/37192975
http://dx.doi.org/10.1016/j.isci.2023.106662

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