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Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a progressive increase in pulmonary artery pressure caused by pathological pulmonary artery remodeling. Here, we demonstrate that endothelial cell (EC) senescence plays a negative role in pulmonary hypertension via juxtacrine...
Autores principales: | Ramadhiani, Risa, Ikeda, Koji, Miyagawa, Kazuya, Ryanto, Gusty Rizky Tough, Tamada, Naoki, Suzuki, Yoko, Kirita, Yuhei, Matoba, Satoaki, Hirata, Ken-ichi, Emoto, Noriaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182325/ https://www.ncbi.nlm.nih.gov/pubmed/37192975 http://dx.doi.org/10.1016/j.isci.2023.106662 |
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