SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis

Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly enhances the BCG vaccine efficacy during primary infection an...

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Detalles Bibliográficos
Autores principales: Bhaskar, Ashima, Pahuja, Isha, Negi, Kriti, Verma, Akanksha, Ghoshal, Antara, Mathew, Babu, Tripathi, Gaurav, Maras, Jaswinder Singh, Chaturvedi, Shivam, Dwivedi, Ved Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182326/
https://www.ncbi.nlm.nih.gov/pubmed/37192966
http://dx.doi.org/10.1016/j.isci.2023.106644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182326/
https://www.ncbi.nlm.nih.gov/pubmed/37192966
http://dx.doi.org/10.1016/j.isci.2023.106644

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