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SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis

Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly enhances the BCG vaccine efficacy during primary infection an...

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Detalles Bibliográficos
Autores principales:	Bhaskar, Ashima, Pahuja, Isha, Negi, Kriti, Verma, Akanksha, Ghoshal, Antara, Mathew, Babu, Tripathi, Gaurav, Maras, Jaswinder Singh, Chaturvedi, Shivam, Dwivedi, Ved Prakash
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182326/ https://www.ncbi.nlm.nih.gov/pubmed/37192966 http://dx.doi.org/10.1016/j.isci.2023.106644

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