Cargando…

The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas

Dysplastic crypt branching (DCB) was recently found in ulcerative colitis‐associated dysplasia. The aim was to assess the frequency and the branching phenotype of DCB in polypoid colorectal tubular adenomas (TA). A total of 3956 DCB were found in the 139 TA: 98% were in asymmetric branching (DCAB) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Rubio, Carlos A., Vieth, Michael, Lang‐Schwarz, Corinna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182366/
https://www.ncbi.nlm.nih.gov/pubmed/36734673
http://dx.doi.org/10.1111/iep.12466
_version_ 1785041756405891072
author Rubio, Carlos A.
Vieth, Michael
Lang‐Schwarz, Corinna
author_facet Rubio, Carlos A.
Vieth, Michael
Lang‐Schwarz, Corinna
author_sort Rubio, Carlos A.
collection PubMed
description Dysplastic crypt branching (DCB) was recently found in ulcerative colitis‐associated dysplasia. The aim was to assess the frequency and the branching phenotype of DCB in polypoid colorectal tubular adenomas (TA). A total of 3956 DCB were found in the 139 TA: 98% were in asymmetric branching (DCAB) and the remaining 2% in symmetric branching (DCSB). A linear correlation was found between DCB frequency and the increasing digital size in TA (p < .05). Using a digital ruler, adenomas were divided into small TA (<5 mm) and larger TA (≥5 mm). The difference between the frequency of DCB in small TA (n = 75) vs. larger TA (n = 64), was significant (p < .05). DCB frequency was not influenced by age, gender or TA localization. In the normal colorectal mucosa (≈2 m(2)), only occasional CSB is found and no CAB. And yet, multiple DCB (mean 16.7 DCB), mostly DCAB, was found in small TA, occupying <5 mm of the mucosal area. In larger TA, as many as 42.1 DCB (mean), mostly DCAB, occurred in merely 7.8 mm (mean) of the colon mucosa. Thus it is suggested that DCB is a standard histologic element of TA. The natural expansion of the adenomatous tissue in larger TA appears to be follow on from newly produced, mostly DCAB, by DCSB and by the accumulation of their dysplastic offspring's progenies. The findings strongly suggest that DCB is a central microstructure in the histological events unfolding in polypoid colorectal TA.
format Online
Article
Text
id pubmed-10182366
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-101823662023-05-14 The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas Rubio, Carlos A. Vieth, Michael Lang‐Schwarz, Corinna Int J Exp Pathol Original Articles Dysplastic crypt branching (DCB) was recently found in ulcerative colitis‐associated dysplasia. The aim was to assess the frequency and the branching phenotype of DCB in polypoid colorectal tubular adenomas (TA). A total of 3956 DCB were found in the 139 TA: 98% were in asymmetric branching (DCAB) and the remaining 2% in symmetric branching (DCSB). A linear correlation was found between DCB frequency and the increasing digital size in TA (p < .05). Using a digital ruler, adenomas were divided into small TA (<5 mm) and larger TA (≥5 mm). The difference between the frequency of DCB in small TA (n = 75) vs. larger TA (n = 64), was significant (p < .05). DCB frequency was not influenced by age, gender or TA localization. In the normal colorectal mucosa (≈2 m(2)), only occasional CSB is found and no CAB. And yet, multiple DCB (mean 16.7 DCB), mostly DCAB, was found in small TA, occupying <5 mm of the mucosal area. In larger TA, as many as 42.1 DCB (mean), mostly DCAB, occurred in merely 7.8 mm (mean) of the colon mucosa. Thus it is suggested that DCB is a standard histologic element of TA. The natural expansion of the adenomatous tissue in larger TA appears to be follow on from newly produced, mostly DCAB, by DCSB and by the accumulation of their dysplastic offspring's progenies. The findings strongly suggest that DCB is a central microstructure in the histological events unfolding in polypoid colorectal TA. John Wiley and Sons Inc. 2023-02-03 /pmc/articles/PMC10182366/ /pubmed/36734673 http://dx.doi.org/10.1111/iep.12466 Text en © 2023 The Authors. International Journal of Experimental Pathology published by John Wiley & Sons Ltd on behalf of Company of the International Journal of Experimental Pathology (CIJEP). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Rubio, Carlos A.
Vieth, Michael
Lang‐Schwarz, Corinna
The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas
title The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas
title_full The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas
title_fullStr The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas
title_full_unstemmed The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas
title_short The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas
title_sort frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182366/
https://www.ncbi.nlm.nih.gov/pubmed/36734673
http://dx.doi.org/10.1111/iep.12466
work_keys_str_mv AT rubiocarlosa thefrequencyofdysplasticbranchingcryptsincolorectalpolypoidtubularadenomas
AT viethmichael thefrequencyofdysplasticbranchingcryptsincolorectalpolypoidtubularadenomas
AT langschwarzcorinna thefrequencyofdysplasticbranchingcryptsincolorectalpolypoidtubularadenomas
AT rubiocarlosa frequencyofdysplasticbranchingcryptsincolorectalpolypoidtubularadenomas
AT viethmichael frequencyofdysplasticbranchingcryptsincolorectalpolypoidtubularadenomas
AT langschwarzcorinna frequencyofdysplasticbranchingcryptsincolorectalpolypoidtubularadenomas