The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326

OBJECTIVES: The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables acute regulation of liver glucokinase to support metabolic demand. The common human GCKR rs1260326:Pro446 > Leu variant within a large linkage disequilibrium region associates with pleiotropic traits including lower Typ...

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Detalles Bibliográficos
Autores principales: Ford, Brian E., Chachra, Shruti S., Rodgers, Katrina, Moonira, Tabassum, Al-Oanzi, Ziad H., Anstee, Quentin M., Reeves, Helen L., Schattenberg, Jörn M., Fairclough, Rebecca J., Smith, David M., Tiniakos, Dina, Agius, Loranne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182400/
https://www.ncbi.nlm.nih.gov/pubmed/37031802
http://dx.doi.org/10.1016/j.molmet.2023.101722

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