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Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis
Matrix assisted laser desorption/ionization imaging has greatly improved our understanding of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here, we demonstrate the application of high-dimensionality reduction/spatial clustering and histopathological annotati...
Autores principales: | Conroy, Lindsey R., Clarke, Harrison A., Allison, Derek B., Valenca, Samuel Santos, Sun, Qi, Hawkinson, Tara R., Young, Lyndsay E. A., Ferreira, Juanita E., Hammonds, Autumn V., Dunne, Jaclyn B., McDonald, Robert J., Absher, Kimberly J., Dong, Brittany E., Bruntz, Ronald C., Markussen, Kia H., Juras, Jelena A., Alilain, Warren J., Liu, Jinze, Gentry, Matthew S., Angel, Peggi M., Waters, Christopher M., Sun, Ramon C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182559/ https://www.ncbi.nlm.nih.gov/pubmed/37179348 http://dx.doi.org/10.1038/s41467-023-38437-1 |
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