A metal‐dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine‐5′‐triphosphate

CTP synthases (CTPS) catalyze the de novo production of CTP using UTP, ATP, and l‐glutamine with the anticancer drug metabolite gemcitabine‐5′‐triphosphate (dF‐dCTP) being one of its most potent nucleotide inhibitors. To delineate the structural origins of this inhibition, we solved the structures o...

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Detalles Bibliográficos
Autores principales: McLeod, Matthew J., Tran, Norman, McCluskey, Gregory D., Gillis, Tom D., Bearne, Stephen L., Holyoak, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182726/
https://www.ncbi.nlm.nih.gov/pubmed/37106216
http://dx.doi.org/10.1002/pro.4648

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