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Robust microtubule dynamics facilitate low-tension kinetochore detachment in metaphase
During mitosis, sister chromatids are stretched apart at their centromeres via their attachment to oppositely oriented kinetochore microtubules. This stretching generates inwardly directed tension across the separated sister centromeres. The cell leverages this tension signal to detect and then corr...
Autores principales: | Parmar, Sneha, Gonzalez, Samuel J., Heckel, Julia M., Mukherjee, Soumya, McClellan, Mark, Clarke, Duncan J., Johansson, Marnie, Tank, Damien, Geisness, Athena, Wood, David K., Gardner, Melissa K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182774/ https://www.ncbi.nlm.nih.gov/pubmed/37166419 http://dx.doi.org/10.1083/jcb.202202085 |
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