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The ancestral haplotype markers HLA -A3 and B7 do not influence the likelihood of advanced hepatic fibrosis or cirrhosis in HFE hemochromatosis

Advanced hepatic fibrosis occurs in up to 25% of individuals with C282Y homozygous hemochromatosis. Our aim was to determine whether human leukocyte antigen (HLA)-A3 and B7 alleles act as genetic modifiers of the likelihood of advanced hepatic fibrosis. Between 1972 and 2013, 133 HFE C282Y homozygou...

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Detalles Bibliográficos
Autores principales:	Olynyk, John K., Grainger, Richard, Currie, Helen, Ramm, Louise E., Ramm, Grant A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183001/ https://www.ncbi.nlm.nih.gov/pubmed/37179448 http://dx.doi.org/10.1038/s41598-023-35028-4

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