Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases

Transcription factor IIH (TFIIH) is a protein assembly essential for transcription initiation and nucleotide excision repair (NER). Yet, understanding of the conformational switching underpinning these diverse TFIIH functions remains fragmentary. TFIIH mechanisms critically depend on two translocase...

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Detalles Bibliográficos
Autores principales: Yu, Jina, Yan, Chunli, Dodd, Thomas, Tsai, Chi-Lin, Tainer, John A., Tsutakawa, Susan E., Ivanov, Ivaylo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183003/
https://www.ncbi.nlm.nih.gov/pubmed/37179334
http://dx.doi.org/10.1038/s41467-023-38416-6

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