Cargando…

Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study

The prevalence of high birth weight or large for gestational age (LGA) infants is increasing, with increasing evidence of pregnancy-related factors that may have long-term impacts on the health of the mother and baby. We aimed to determine the association between excessive fetal growth, specifically...

Descripción completa

Detalles Bibliográficos
Autores principales: Qian, Naisi, Yang, Qing, Chen, Lei, Jin, Shan, Qiao, Jiaying, Cai, Renzhi, Wu, Chunxiao, Yu, Huiting, Gu, Kai, Wang, Chunfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183036/
https://www.ncbi.nlm.nih.gov/pubmed/37179417
http://dx.doi.org/10.1038/s41598-023-33664-4
_version_ 1785041873246617600
author Qian, Naisi
Yang, Qing
Chen, Lei
Jin, Shan
Qiao, Jiaying
Cai, Renzhi
Wu, Chunxiao
Yu, Huiting
Gu, Kai
Wang, Chunfang
author_facet Qian, Naisi
Yang, Qing
Chen, Lei
Jin, Shan
Qiao, Jiaying
Cai, Renzhi
Wu, Chunxiao
Yu, Huiting
Gu, Kai
Wang, Chunfang
author_sort Qian, Naisi
collection PubMed
description The prevalence of high birth weight or large for gestational age (LGA) infants is increasing, with increasing evidence of pregnancy-related factors that may have long-term impacts on the health of the mother and baby. We aimed to determine the association between excessive fetal growth, specifically LGA and macrosomia, and subsequent maternal cancer by performing a prospective population-based cohort study. The data set was based on the Shanghai Birth Registry and Shanghai Cancer Registry, with medical records from the Shanghai Health Information Network as a supplement. Macrosomia and LGA prevalence was higher in women who developed cancer than in women who did not. Having an LGA child in the first delivery was associated with a subsequently increased risk of maternal cancer (hazard ratio [HR] = 1.08, 95% confidence interval [CI] 1.04–1.11). Additionally, in the last and heaviest deliveries, there were similar associations between LGA births and maternal cancer rates (HR = 1.08, 95% CI 1.04–1.12; HR = 1.08, 95% CI 1.05–1.12, respectively). Furthermore, a substantially increased trend in the risk of maternal cancer was associated with birth weights exceeding 2500 g. Our study supports the association between LGA births and increased risks of maternal cancer, but this risk requires further investigation.
format Online
Article
Text
id pubmed-10183036
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-101830362023-05-15 Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study Qian, Naisi Yang, Qing Chen, Lei Jin, Shan Qiao, Jiaying Cai, Renzhi Wu, Chunxiao Yu, Huiting Gu, Kai Wang, Chunfang Sci Rep Article The prevalence of high birth weight or large for gestational age (LGA) infants is increasing, with increasing evidence of pregnancy-related factors that may have long-term impacts on the health of the mother and baby. We aimed to determine the association between excessive fetal growth, specifically LGA and macrosomia, and subsequent maternal cancer by performing a prospective population-based cohort study. The data set was based on the Shanghai Birth Registry and Shanghai Cancer Registry, with medical records from the Shanghai Health Information Network as a supplement. Macrosomia and LGA prevalence was higher in women who developed cancer than in women who did not. Having an LGA child in the first delivery was associated with a subsequently increased risk of maternal cancer (hazard ratio [HR] = 1.08, 95% confidence interval [CI] 1.04–1.11). Additionally, in the last and heaviest deliveries, there were similar associations between LGA births and maternal cancer rates (HR = 1.08, 95% CI 1.04–1.12; HR = 1.08, 95% CI 1.05–1.12, respectively). Furthermore, a substantially increased trend in the risk of maternal cancer was associated with birth weights exceeding 2500 g. Our study supports the association between LGA births and increased risks of maternal cancer, but this risk requires further investigation. Nature Publishing Group UK 2023-05-13 /pmc/articles/PMC10183036/ /pubmed/37179417 http://dx.doi.org/10.1038/s41598-023-33664-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qian, Naisi
Yang, Qing
Chen, Lei
Jin, Shan
Qiao, Jiaying
Cai, Renzhi
Wu, Chunxiao
Yu, Huiting
Gu, Kai
Wang, Chunfang
Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study
title Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study
title_full Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study
title_fullStr Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study
title_full_unstemmed Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study
title_short Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study
title_sort association between excessive fetal growth and maternal cancer in shanghai, china: a large, population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183036/
https://www.ncbi.nlm.nih.gov/pubmed/37179417
http://dx.doi.org/10.1038/s41598-023-33664-4
work_keys_str_mv AT qiannaisi associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT yangqing associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT chenlei associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT jinshan associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT qiaojiaying associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT cairenzhi associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT wuchunxiao associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT yuhuiting associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT gukai associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy
AT wangchunfang associationbetweenexcessivefetalgrowthandmaternalcancerinshanghaichinaalargepopulationbasedcohortstudy