FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation

FUS is an RNA-binding protein involved in familiar forms of ALS and FTLD that also assembles into fibrillar cytoplasmic aggregates in some neurodegenerative diseases without genetic causes. The self-adhesive prion-like domain in FUS generates reversible condensates via the liquid–liquid phase separa...

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Detalles Bibliográficos
Autores principales: Bertrand, Emilie, Demongin, Clément, Dobra, Ioana, Rengifo-Gonzalez, Juan Carlos, Singatulina, Anastasia S., Sukhanova, Maria V., Lavrik, Olga I., Pastré, David, Hamon, Loic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183042/
https://www.ncbi.nlm.nih.gov/pubmed/37179431
http://dx.doi.org/10.1038/s41598-023-34558-1

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