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Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report

This case describes a rare presentation of a diffuse large B-cell lymphoma not otherwise specified (DLBC NOS) in the gallbladder. We report the case of an 89-year-old male who initially presented with a two-week history of weakness and abdominal discomfort. We performed laparoscopic cholecystectomy...

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Autores principales: Rössler, Fabian, Sachs, Alexandra, Bieri, Uwe, Kuzmanic, Boris, Ballova, Veronika, Schneider, Ulrich, Singer, Gad, Nocito, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183092/
https://www.ncbi.nlm.nih.gov/pubmed/37193435
http://dx.doi.org/10.7759/cureus.37552
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author Rössler, Fabian
Sachs, Alexandra
Bieri, Uwe
Kuzmanic, Boris
Ballova, Veronika
Schneider, Ulrich
Singer, Gad
Nocito, Antonio
author_facet Rössler, Fabian
Sachs, Alexandra
Bieri, Uwe
Kuzmanic, Boris
Ballova, Veronika
Schneider, Ulrich
Singer, Gad
Nocito, Antonio
author_sort Rössler, Fabian
collection PubMed
description This case describes a rare presentation of a diffuse large B-cell lymphoma not otherwise specified (DLBC NOS) in the gallbladder. We report the case of an 89-year-old male who initially presented with a two-week history of weakness and abdominal discomfort. We performed laparoscopic cholecystectomy for suspicion of acute cholecystitis. After the initial uneventful course, readmission occurred for persisting weakness a few weeks after surgery. Computed tomography revealed progressive retroperitoneal lymphadenopathy. With new emerging neurological symptoms, taking into account the histopathological findings of the gallbladder specimen, the diagnosis of DLBCL NOS was confirmed. Due to the rapid clinical deterioration and extranodal involvement, the patient opted against further therapy. When the suspicion of cholecystitis is inconclusive, rare differential diagnoses need to be considered. This analysis may improve the understanding of the presentation and course of DLBC NOS in abdominal organs and could form the basis for a systematic review to improve diagnosis and therapy.
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spelling pubmed-101830922023-05-15 Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report Rössler, Fabian Sachs, Alexandra Bieri, Uwe Kuzmanic, Boris Ballova, Veronika Schneider, Ulrich Singer, Gad Nocito, Antonio Cureus Pathology This case describes a rare presentation of a diffuse large B-cell lymphoma not otherwise specified (DLBC NOS) in the gallbladder. We report the case of an 89-year-old male who initially presented with a two-week history of weakness and abdominal discomfort. We performed laparoscopic cholecystectomy for suspicion of acute cholecystitis. After the initial uneventful course, readmission occurred for persisting weakness a few weeks after surgery. Computed tomography revealed progressive retroperitoneal lymphadenopathy. With new emerging neurological symptoms, taking into account the histopathological findings of the gallbladder specimen, the diagnosis of DLBCL NOS was confirmed. Due to the rapid clinical deterioration and extranodal involvement, the patient opted against further therapy. When the suspicion of cholecystitis is inconclusive, rare differential diagnoses need to be considered. This analysis may improve the understanding of the presentation and course of DLBC NOS in abdominal organs and could form the basis for a systematic review to improve diagnosis and therapy. Cureus 2023-04-14 /pmc/articles/PMC10183092/ /pubmed/37193435 http://dx.doi.org/10.7759/cureus.37552 Text en Copyright © 2023, Rössler et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Rössler, Fabian
Sachs, Alexandra
Bieri, Uwe
Kuzmanic, Boris
Ballova, Veronika
Schneider, Ulrich
Singer, Gad
Nocito, Antonio
Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report
title Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report
title_full Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report
title_fullStr Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report
title_full_unstemmed Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report
title_short Extranodal Diffuse Large B-cell Lymphoma With Primary Clinical Presentation as Acute Cholecystitis: A Case Report
title_sort extranodal diffuse large b-cell lymphoma with primary clinical presentation as acute cholecystitis: a case report
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183092/
https://www.ncbi.nlm.nih.gov/pubmed/37193435
http://dx.doi.org/10.7759/cureus.37552
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