Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation

Lacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead...

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Autores principales: Takai, Chihiro, Misumi, Kayo, Kaito, Daiki, Nishida, Hiroaki, Yoshii, Masami, Yamada, So, Kobayashi, Takaomi, Koinuma, Toshitaka, Kadoya, Takashi, Kimura, Takuya, Hagiwara, Yoshihiro, Ogura, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183285/
https://www.ncbi.nlm.nih.gov/pubmed/36104195
http://dx.doi.org/10.2169/internalmedicine.0145-22
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author Takai, Chihiro
Misumi, Kayo
Kaito, Daiki
Nishida, Hiroaki
Yoshii, Masami
Yamada, So
Kobayashi, Takaomi
Koinuma, Toshitaka
Kadoya, Takashi
Kimura, Takuya
Hagiwara, Yoshihiro
Ogura, Takayuki
author_facet Takai, Chihiro
Misumi, Kayo
Kaito, Daiki
Nishida, Hiroaki
Yoshii, Masami
Yamada, So
Kobayashi, Takaomi
Koinuma, Toshitaka
Kadoya, Takashi
Kimura, Takuya
Hagiwara, Yoshihiro
Ogura, Takayuki
author_sort Takai, Chihiro
collection PubMed
description Lacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead to cardiovascular side effects, especially in patients with electrical conduction system disorders. We herein report a case of life-threatening cardiac arrhythmia caused by lacosamide intoxication that was successfully treated with veno-arterial extracorporeal membrane oxygenation.
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spelling pubmed-101832852023-05-15 Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation Takai, Chihiro Misumi, Kayo Kaito, Daiki Nishida, Hiroaki Yoshii, Masami Yamada, So Kobayashi, Takaomi Koinuma, Toshitaka Kadoya, Takashi Kimura, Takuya Hagiwara, Yoshihiro Ogura, Takayuki Intern Med Case Report Lacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead to cardiovascular side effects, especially in patients with electrical conduction system disorders. We herein report a case of life-threatening cardiac arrhythmia caused by lacosamide intoxication that was successfully treated with veno-arterial extracorporeal membrane oxygenation. The Japanese Society of Internal Medicine 2022-09-13 2023-04-15 /pmc/articles/PMC10183285/ /pubmed/36104195 http://dx.doi.org/10.2169/internalmedicine.0145-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takai, Chihiro
Misumi, Kayo
Kaito, Daiki
Nishida, Hiroaki
Yoshii, Masami
Yamada, So
Kobayashi, Takaomi
Koinuma, Toshitaka
Kadoya, Takashi
Kimura, Takuya
Hagiwara, Yoshihiro
Ogura, Takayuki
Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation
title Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation
title_full Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation
title_fullStr Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation
title_full_unstemmed Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation
title_short Lacosamide Intoxication-induced Wide QRS Tachycardia Successfully Treated with Veno-arterial Extracorporeal Membrane Oxygenation
title_sort lacosamide intoxication-induced wide qrs tachycardia successfully treated with veno-arterial extracorporeal membrane oxygenation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183285/
https://www.ncbi.nlm.nih.gov/pubmed/36104195
http://dx.doi.org/10.2169/internalmedicine.0145-22
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