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Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis
BACKGROUND: To date, dozens of systematic reviews (SRs) and meta-analyses (MAs) summarize the effectiveness of preventive interventions for perinatal depression. However, the results are inconclusive, making an urgent need to step up to higher levels of evidence synthesis. AIMS: To summarize and com...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier/North-Holland
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183436/ https://www.ncbi.nlm.nih.gov/pubmed/36958130 http://dx.doi.org/10.1016/j.genhosppsych.2023.03.007 |
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author | Motrico, Emma Bina, Rena Kassianos, Angelos P. Le, Huynh-Nhu Mateus, Vera Oztekin, Deniz Rodriguez- Muñoz, Maria F. Moreno-Peral, Patricia Conejo-Cerón, Sonia |
author_facet | Motrico, Emma Bina, Rena Kassianos, Angelos P. Le, Huynh-Nhu Mateus, Vera Oztekin, Deniz Rodriguez- Muñoz, Maria F. Moreno-Peral, Patricia Conejo-Cerón, Sonia |
author_sort | Motrico, Emma |
collection | PubMed |
description | BACKGROUND: To date, dozens of systematic reviews (SRs) and meta-analyses (MAs) summarize the effectiveness of preventive interventions for perinatal depression. However, the results are inconclusive, making an urgent need to step up to higher levels of evidence synthesis. AIMS: To summarize and compare the evidence from the SR&MA examining the effectiveness of all types of interventions for preventing perinatal depression. METHOD: PubMed, PsycINFO, Cochrane Database of Systematic Reviews and OpenGrey were searched from inception to December 2022. We selected SR&MA of randomized controlled trials (RCTs) that compared all types of preventive interventions for perinatal depression with control groups whose outcome was the reduction of depressive symptoms and/or incidence of new cases of perinatal depression (PROSPERO: CRD42020173125). RESULTS: A total of 19 SRs and MAs evaluated 152 unique RCTs that included 83,408 women from 26 countries and five continents. The median effect size for any intervention was SMD = 0.29 (95% CI: 0.20 to 0.38). Exercise/physical activity-based, psychological, and any type of intervention showed median effect sizes of 0.43, 0.28 and 0.36, respectively. The degree of overlap among RCTs was slight. According to AMSTAR-2, 79% of them were rated as low or critically low-quality. The strength of evidence, according to GRADE, was poorly reported and, in most cases, was low. CONCLUSIONS: Exercise/physical activity-based and psychological interventions have a small-to-medium effect on reducing perinatal depressive symptoms. There is insufficient evidence to conclude that dietary supplements and pharmacological interventions are effective in preventing perinatal depression. There is a need for high-quality SR&MA of RCTs, mainly focusing on universal preventive interventions. |
format | Online Article Text |
id | pubmed-10183436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier/North-Holland |
record_format | MEDLINE/PubMed |
spelling | pubmed-101834362023-05-16 Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis Motrico, Emma Bina, Rena Kassianos, Angelos P. Le, Huynh-Nhu Mateus, Vera Oztekin, Deniz Rodriguez- Muñoz, Maria F. Moreno-Peral, Patricia Conejo-Cerón, Sonia Gen Hosp Psychiatry Article BACKGROUND: To date, dozens of systematic reviews (SRs) and meta-analyses (MAs) summarize the effectiveness of preventive interventions for perinatal depression. However, the results are inconclusive, making an urgent need to step up to higher levels of evidence synthesis. AIMS: To summarize and compare the evidence from the SR&MA examining the effectiveness of all types of interventions for preventing perinatal depression. METHOD: PubMed, PsycINFO, Cochrane Database of Systematic Reviews and OpenGrey were searched from inception to December 2022. We selected SR&MA of randomized controlled trials (RCTs) that compared all types of preventive interventions for perinatal depression with control groups whose outcome was the reduction of depressive symptoms and/or incidence of new cases of perinatal depression (PROSPERO: CRD42020173125). RESULTS: A total of 19 SRs and MAs evaluated 152 unique RCTs that included 83,408 women from 26 countries and five continents. The median effect size for any intervention was SMD = 0.29 (95% CI: 0.20 to 0.38). Exercise/physical activity-based, psychological, and any type of intervention showed median effect sizes of 0.43, 0.28 and 0.36, respectively. The degree of overlap among RCTs was slight. According to AMSTAR-2, 79% of them were rated as low or critically low-quality. The strength of evidence, according to GRADE, was poorly reported and, in most cases, was low. CONCLUSIONS: Exercise/physical activity-based and psychological interventions have a small-to-medium effect on reducing perinatal depressive symptoms. There is insufficient evidence to conclude that dietary supplements and pharmacological interventions are effective in preventing perinatal depression. There is a need for high-quality SR&MA of RCTs, mainly focusing on universal preventive interventions. Elsevier/North-Holland 2023 /pmc/articles/PMC10183436/ /pubmed/36958130 http://dx.doi.org/10.1016/j.genhosppsych.2023.03.007 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Motrico, Emma Bina, Rena Kassianos, Angelos P. Le, Huynh-Nhu Mateus, Vera Oztekin, Deniz Rodriguez- Muñoz, Maria F. Moreno-Peral, Patricia Conejo-Cerón, Sonia Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis |
title | Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis |
title_full | Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis |
title_fullStr | Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis |
title_full_unstemmed | Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis |
title_short | Effectiveness of interventions to prevent perinatal depression: An umbrella review of systematic reviews and meta-analysis |
title_sort | effectiveness of interventions to prevent perinatal depression: an umbrella review of systematic reviews and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183436/ https://www.ncbi.nlm.nih.gov/pubmed/36958130 http://dx.doi.org/10.1016/j.genhosppsych.2023.03.007 |
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