SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

Genomic MET amplification and exon 14 skipping are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met inhibitors (c-Metis), yet the overall clinical benefit of this strategy is quite limited....

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Detalles Bibliográficos
Autores principales: Zhou, Ji, Zhang, Xu-Chao, Xue, Shan, Dai, Mengdi, Wang, Yueliang, Peng, Xia, Chen, Jianjiao, Wang, Xinyi, Shen, Yanyan, Qin, Hui, Chen, Bi, Zheng, Yu, Gao, Xiwen, Xie, Zuoquan, Ding, Jian, Jiang, Handong, Wu, Yi-Long, Geng, Meiyu, Ai, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183461/
https://www.ncbi.nlm.nih.gov/pubmed/37183231
http://dx.doi.org/10.1038/s41392-023-01403-w

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