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Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma

BACKGROUND: Lymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare variant of intrahepatic cholangiocarcinoma. Epstein–Barr virus (EBV) infection was considered to play a pivotal role in the tumorigenesis of LEL-ICC. It is difficult to diagnosis of LEL-ICC due to the lack of spec...

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Autores principales: Liu, Fei, Xu, Qing, Regmi, Parbatraj, Li, Fu-Yu, Lin, Yi-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183565/
https://www.ncbi.nlm.nih.gov/pubmed/37197425
http://dx.doi.org/10.3389/fonc.2023.1146933
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author Liu, Fei
Xu, Qing
Regmi, Parbatraj
Li, Fu-Yu
Lin, Yi-Xin
author_facet Liu, Fei
Xu, Qing
Regmi, Parbatraj
Li, Fu-Yu
Lin, Yi-Xin
author_sort Liu, Fei
collection PubMed
description BACKGROUND: Lymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare variant of intrahepatic cholangiocarcinoma. Epstein–Barr virus (EBV) infection was considered to play a pivotal role in the tumorigenesis of LEL-ICC. It is difficult to diagnosis of LEL-ICC due to the lack of specific features regarding the laboratory test results and imaging findings. At present, the diagnosis of LEL-ICC mainly depends on the histopathologic and immunohistochemical examinations. In addition, the prognosis of LEL-ICC was better than classical cholangiocarcinomas. To our knowledge, only few cases of LEL-ICC have been reported in the literature. CASE PRESENTATION: We presented a case of a 32-year-old Chinese female with LEL-ICC. She had a 6-month history of upper abdominal pain. The magnetic resonance imaging (MRI) showed a 1.1× 1.3 cm lesion in the left lobe of liver, appearing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The patient underwent laparoscopic left lateral sectionectomy. The postoperative histopathologic and immunohistochemical examinations results allowed for the definitive diagnosis of LEL-ICC. The patient was free from tumor recurrence after a 28 months follow-up. CONCLUSION: In this study, we reported a rare case of LEL-ICC associated with both HBV and EBV infection. EBV infection might play a pivotal role in the carcinogenesis of LEL-ICC, and surgical resection is still the most effective treatment at present. Further research on the etiology and treatment strategies of LEL-ICC is required.
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spelling pubmed-101835652023-05-16 Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma Liu, Fei Xu, Qing Regmi, Parbatraj Li, Fu-Yu Lin, Yi-Xin Front Oncol Oncology BACKGROUND: Lymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare variant of intrahepatic cholangiocarcinoma. Epstein–Barr virus (EBV) infection was considered to play a pivotal role in the tumorigenesis of LEL-ICC. It is difficult to diagnosis of LEL-ICC due to the lack of specific features regarding the laboratory test results and imaging findings. At present, the diagnosis of LEL-ICC mainly depends on the histopathologic and immunohistochemical examinations. In addition, the prognosis of LEL-ICC was better than classical cholangiocarcinomas. To our knowledge, only few cases of LEL-ICC have been reported in the literature. CASE PRESENTATION: We presented a case of a 32-year-old Chinese female with LEL-ICC. She had a 6-month history of upper abdominal pain. The magnetic resonance imaging (MRI) showed a 1.1× 1.3 cm lesion in the left lobe of liver, appearing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The patient underwent laparoscopic left lateral sectionectomy. The postoperative histopathologic and immunohistochemical examinations results allowed for the definitive diagnosis of LEL-ICC. The patient was free from tumor recurrence after a 28 months follow-up. CONCLUSION: In this study, we reported a rare case of LEL-ICC associated with both HBV and EBV infection. EBV infection might play a pivotal role in the carcinogenesis of LEL-ICC, and surgical resection is still the most effective treatment at present. Further research on the etiology and treatment strategies of LEL-ICC is required. Frontiers Media S.A. 2023-05-01 /pmc/articles/PMC10183565/ /pubmed/37197425 http://dx.doi.org/10.3389/fonc.2023.1146933 Text en Copyright © 2023 Liu, Xu, Regmi, Li and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Fei
Xu, Qing
Regmi, Parbatraj
Li, Fu-Yu
Lin, Yi-Xin
Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
title Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
title_full Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
title_fullStr Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
title_full_unstemmed Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
title_short Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
title_sort case report: primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183565/
https://www.ncbi.nlm.nih.gov/pubmed/37197425
http://dx.doi.org/10.3389/fonc.2023.1146933
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