CTLA4 mRNA is downregulated by miR-155 in regulatory T cells, and reduced blood CTLA4 levels are associated with poor prognosis in metastatic melanoma patients

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an immune checkpoint expressed in regulatory T (Treg) cells and activated T lymphocytes. Despite its potential as a treatment strategy for melanoma, CTLA-4 inhibition has limited efficacy. Using data from The Cancer Genome Atlas (TCGA) melanoma...

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Detalles Bibliográficos
Autores principales: Vaddi, Prasanna Kumar, Osborne, Douglas Grant, Nicklawsky, Andrew, Williams, Nazanin K., Menon, Dinoop Ravindran, Smith, Derek, Mayer, Jonathan, Reid, Anna, Domenico, Joanne, Nguyen, Giang Huong, Robinson, William A., Ziman, Melanie, Gao, Dexiang, Zhai, Zili, Fujita, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183574/
https://www.ncbi.nlm.nih.gov/pubmed/37197667
http://dx.doi.org/10.3389/fimmu.2023.1173035

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