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Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection

BACKGROUND: Extra-urogenital infections due to Mycoplasma hominis (M. hominis) are rare, particularly co-infection with Pseudomonas aeruginosa (P. aeruginosa). Herein, we report on a patient who was co-infected and successfully treated despite delayed treatment. CASE PRESENTATION: We reported the ca...

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Autores principales: Huang, Shi-Mei, Tang, Yu-Rong, Wang, Ji-Liang, Wang, Xiao-Zhen, Zhang, Yuan-Yuan, Pan, Su-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183579/
https://www.ncbi.nlm.nih.gov/pubmed/37197207
http://dx.doi.org/10.3389/fcimb.2023.1159891
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author Huang, Shi-Mei
Tang, Yu-Rong
Wang, Ji-Liang
Wang, Xiao-Zhen
Zhang, Yuan-Yuan
Pan, Su-Fei
author_facet Huang, Shi-Mei
Tang, Yu-Rong
Wang, Ji-Liang
Wang, Xiao-Zhen
Zhang, Yuan-Yuan
Pan, Su-Fei
author_sort Huang, Shi-Mei
collection PubMed
description BACKGROUND: Extra-urogenital infections due to Mycoplasma hominis (M. hominis) are rare, particularly co-infection with Pseudomonas aeruginosa (P. aeruginosa). Herein, we report on a patient who was co-infected and successfully treated despite delayed treatment. CASE PRESENTATION: We reported the case of a 43-year-old man with M. hominis and P. aeruginosa co-infection after a traffic accident. The patient developed a fever and severe infection despite postoperative antimicrobial therapies. The blood culture of wound tissues was positive for P. aeruginosa. Meanwhile, culturing of blood and wound samples showed pinpoint-sized colonies on blood agar plates and fried-egg-type colonies on mycoplasma medium, which were identified as M. hominis by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rRNA sequencing. Based on antibiotic susceptibility and symptoms, ceftazidime–avibactam and moxifloxacin were administered for P. aeruginosa infection. Meanwhile, after the failure of a series of anti-infective agents, M. hominis and P. aeruginosa co-infection was successfully treated with a minocycline-based regimen and polymyxin B. CONCLUSION: The co-infection with M. hominis and P. aeruginosa was successfully treated with anti-infective agents despite delayed treatment, providing information for the management of double infection.
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spelling pubmed-101835792023-05-16 Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection Huang, Shi-Mei Tang, Yu-Rong Wang, Ji-Liang Wang, Xiao-Zhen Zhang, Yuan-Yuan Pan, Su-Fei Front Cell Infect Microbiol Cellular and Infection Microbiology BACKGROUND: Extra-urogenital infections due to Mycoplasma hominis (M. hominis) are rare, particularly co-infection with Pseudomonas aeruginosa (P. aeruginosa). Herein, we report on a patient who was co-infected and successfully treated despite delayed treatment. CASE PRESENTATION: We reported the case of a 43-year-old man with M. hominis and P. aeruginosa co-infection after a traffic accident. The patient developed a fever and severe infection despite postoperative antimicrobial therapies. The blood culture of wound tissues was positive for P. aeruginosa. Meanwhile, culturing of blood and wound samples showed pinpoint-sized colonies on blood agar plates and fried-egg-type colonies on mycoplasma medium, which were identified as M. hominis by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rRNA sequencing. Based on antibiotic susceptibility and symptoms, ceftazidime–avibactam and moxifloxacin were administered for P. aeruginosa infection. Meanwhile, after the failure of a series of anti-infective agents, M. hominis and P. aeruginosa co-infection was successfully treated with a minocycline-based regimen and polymyxin B. CONCLUSION: The co-infection with M. hominis and P. aeruginosa was successfully treated with anti-infective agents despite delayed treatment, providing information for the management of double infection. Frontiers Media S.A. 2023-05-01 /pmc/articles/PMC10183579/ /pubmed/37197207 http://dx.doi.org/10.3389/fcimb.2023.1159891 Text en Copyright © 2023 Huang, Tang, Wang, Wang, Zhang and Pan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Huang, Shi-Mei
Tang, Yu-Rong
Wang, Ji-Liang
Wang, Xiao-Zhen
Zhang, Yuan-Yuan
Pan, Su-Fei
Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection
title Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection
title_full Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection
title_fullStr Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection
title_full_unstemmed Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection
title_short Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection
title_sort case report: double trouble: a rare case of successfully treated mycoplasma hominis and pseudomonas aeruginosa co-infection
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183579/
https://www.ncbi.nlm.nih.gov/pubmed/37197207
http://dx.doi.org/10.3389/fcimb.2023.1159891
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