Cargando…

Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the NK function in Hu-BLT mice

INTRODUCTION AND METHODS: In this study we report that sequential treatment of supercharged NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both poorly differentiated and well differentiated tumors in-vivo in humanized-BLT mice. BACKGROUND AND RESULTS: sNK cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaur, Kawaljit, Chen, Po-Chun, Ko, Meng-Wei, Mei, Ao, Senjor, Emanuela, Malarkannan, Subramaniam, Kos, Janko, Jewett, Anahid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183580/ https://www.ncbi.nlm.nih.gov/pubmed/37197660 http://dx.doi.org/10.3389/fimmu.2023.1132807

Ejemplares similares

Differences in Tumor Growth and Differentiation in NSG and Humanized-BLT Mice; Analysis of Human vs. Humanized-BLT-Derived NK Expansion and Functions
por: Kaur, Kawaljit, et al.
Publicado: (2022)

Suppression of Gingival NK Cells in Precancerous and Cancerous Stages of Pancreatic Cancer in KC and BLT-Humanized Mice
por: Kaur, Kawaljit, et al.
Publicado: (2017)

Probiotic-Treated Super-Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu-BLT Mice
por: Kaur, Kawaljit, et al.
Publicado: (2019)

Cysteine Cathepsins as Regulators of the Cytotoxicity of NK and T Cells
por: Perišić Nanut, Milica, et al.
Publicado: (2014)

Augmentation of IFN-γ by bone marrow derived immune cells in the presence of severe suppression of IFN-γ in gingivae induced by zoledronic acid and denosumab in Hu-BLT mice model of ONJ
por: Kaur, Kawaljit, et al.
Publicado: (2023)

Characterizing hepatocellular carcinoma stem markers and their corresponding susceptibility to NK-cell based immunotherapy
por: Chiang, Jason, et al.
Publicado: (2023)

Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells
por: Kaur, Kawaljit, et al.
Publicado: (2020)

Novel Strategy to Expand Super-Charged NK Cells with Significant Potential to Lyse and Differentiate Cancer Stem Cells: Differences in NK Expansion and Function between Healthy and Cancer Patients
por: Kaur, Kawaljit, et al.
Publicado: (2017)

The Role of microRNAs in NK Cell Development and Function
por: Nanbakhsh, Arash, et al.
Publicado: (2021)

Transcriptomic perspectives of memory-like NK cells and aging
por: Wang, Dandan, et al.
Publicado: (2022)

Innatus immunis: Evolving paradigm of adaptive NK cells
por: Khalil, Mohamed, et al.
Publicado: (2022)

Defective Patient NK Function Is Reversed by AJ2 Probiotic Bacteria or Addition of Allogeneic Healthy Monocytes
por: Ko, Meng-Wei, et al.
Publicado: (2022)

Differential Contribution of BLT(1) and BLT(2) to Leukotriene B(4)-Induced Human NK Cell Cytotoxicity and Migration
por: Wang, Meng, et al.
Publicado: (2015)

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance
por: Hashemi, Elaheh, et al.
Publicado: (2020)

Transcriptional Regulation of NK Cell Development by mTOR Complexes
por: Yang, Chao, et al.
Publicado: (2020)

Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs
por: Kozlowska, Anna Karolina, et al.
Publicado: (2017)

ADCC against MICA/B Is Mediated against Differentiated Oral and Pancreatic and Not Stem-Like/Poorly Differentiated Tumors by the NK Cells; Loss in Cancer Patients due to Down-Modulation of CD16 Receptor
por: Kaur, Kawaljit, et al.
Publicado: (2021)

Implications of a ‘Third Signal’ in NK Cells
por: Khalil, Mohamed, et al.
Publicado: (2021)

Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice
por: Tseng, Han-Ching, et al.
Publicado: (2015)

The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions
por: Jewett, Anahid
Publicado: (2020)

Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders
por: Senjor, Emanuela, et al.
Publicado: (2023)

Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10
por: Bui, Vickie T., et al.
Publicado: (2015)

The Potential Role of Cytotoxic Immune Effectors in Induction, Progression and Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)
por: Kaur, Kawaljit, et al.
Publicado: (2022)

Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells
por: Tseng, Han-Ching, et al.
Publicado: (2015)

Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation
por: Tseng, Han-Ching, et al.
Publicado: (2015)

IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection
por: Kumar, Pawan, et al.
Publicado: (2012)

Erratum: Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation
por: Tseng, Han-Ching, et al.
Publicado: (2015)

Split anergized natural killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion
por: Tseng, Han-Ching, et al.
Publicado: (2015)

Cysteine Cathepsins in Tumor-Associated Immune Cells
por: Jakoš, Tanja, et al.
Publicado: (2019)

The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
por: Guo, Hailong, et al.
Publicado: (2008)

Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells
por: Gerbec, Zachary J., et al.
Publicado: (2020)

Cathepsin X Activity Does Not Affect NK-Target Cell Synapse but Is Rather Distributed to Cytotoxic Granules
por: Jakoš, Tanja, et al.
Publicado: (2021)

IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection
por: Kumar, Pawan, et al.
Publicado: (2019)

Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature
por: Yang, Chao, et al.
Publicado: (2020)

Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes
por: Awasthi, Aradhana, et al.
Publicado: (2010)

Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway
por: Idso, John M., et al.
Publicado: (2020)

Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F
por: Magister, Špela, et al.
Publicado: (2015)

Cystatin F Affects Natural Killer Cell Cytotoxicity
por: Perišić Nanut, Milica, et al.
Publicado: (2017)

Natural Killer Cells: Diverse Functions in Tumor Immunity and Defects in Pre-neoplastic and Neoplastic Stages of Tumorigenesis
por: Jewett, Anahid, et al.
Publicado: (2019)

Strategies to Rescue Mesenchymal Stem Cells (MSCs) and Dental Pulp Stem Cells (DPSCs) from NK Cell Mediated Cytotoxicity
por: Jewett, Anahid, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_7nt0gu97ee5eq80qtm233360h6