Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc(Min/+) mice: possible mechanisms of radiation tumorigenesis

Age at exposure is a major modifier of radiation-induced carcinogenesis. We used mouse models to elucidate the mechanism underlying age-related susceptibility to radiation-induced tumorigenesis. Radiation exposure in infants was effective at inducing tumors in B6/B6-Chr18(MSM)-F1 Apc(Min/+) mice. Lo...

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Detalles Bibliográficos
Autores principales: Sasatani, Megumi, Shimura, Tsutomu, Doi, Kazutaka, Zaharieva, Elena Karamfilova, Li, Jianxiang, Iizuka, Daisuke, Etoh, Shinpei, Sotomaru, Yusuke, Kamiya, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Carcinogenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183640/
https://www.ncbi.nlm.nih.gov/pubmed/36546734
http://dx.doi.org/10.1093/carcin/bgac100

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