Cargando…

Phase I NT-501 Ciliary Neurotrophic Factor Implant Trial for Primary Open-Angle Glaucoma: Safety, Neuroprotection, and Neuroenhancement

PURPOSE: To assess the safety and efficacy of a ciliary neurotrophic factor (CNTF) intraocular implant on neuroprotection and neuroenhancement in glaucoma. DESIGN: Open-label, prospective, phase I clinical trial. PARTICIPANTS: A total of 11 participants were diagnosed with primary open-angle glaucom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goldberg, Jeffrey L., Beykin, Gala, Satterfield, Kellie R., Nuñez, Mariana, Lam, Byron L., Albini, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Neuroprotection, Neuroenhancement, and Neuroregeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183667/ https://www.ncbi.nlm.nih.gov/pubmed/37197702 http://dx.doi.org/10.1016/j.xops.2023.100298

Ejemplares similares

Temporal Alterations of Sphingolipids in Optic Nerves After Indirect Traumatic Optic Neuropathy
por: Chauhan, Muhammad Z., et al.
Publicado: (2022)

Younger age is associated with greater early neurocognitive decline postcardiopulmonary bypass
por: Anderson, Kelsey, et al.
Publicado: (2020)

Neuroprotection, Neuroenhancement, and Neuroregeneration of the Retina and Optic Nerve
por: Johnson, Thomas V., et al.
Publicado: (2022)

Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma
por: Lin, Cheng-Wen, et al.
Publicado: (2018)

Ciliary neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract
por: Shpak, Alexander A., et al.
Publicado: (2017)

Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas
por: Do Rhee, Kun, et al.
Publicado: (2022)

Parvalbumin interneurons and calretinin fibers arising from the thalamic nucleus reuniens degenerate in the subiculum after kainic acid-induced seizures
por: Drexel, M., et al.
Publicado: (2011)

Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn)
por: Batelli, S., et al.
Publicado: (2011)

Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats
por: Ehrlich, D., et al.
Publicado: (2012)

Brain-derived neurotrophic factor prevents beta- amyloid-induced apoptosis of pheochromocytoma cells by regulating Bax/Bcl-2 expression☆
por: Sun, Zhikun, et al.
Publicado: (2012)

In vitro neuroprotective effects of ciliary neurotrophic factor on dorsal root ganglion neurons with glutamate-induced neurotoxicity
por: Wen, Shu-yun, et al.
Publicado: (2017)

How Realistic Are the Scientific Assumptions of the Neuroenhancement Debate? Assessing the Pharmacological Optimism and Neuroenhancement Prevalence Hypotheses
por: Schleim, Stephan, et al.
Publicado: (2018)

The is and ought of the Ethics of Neuroenhancement: Mind the Gap
por: Forlini, Cynthia, et al.
Publicado: (2016)

Neuroenhancement of Exposure Therapy in Anxiety Disorders
por: Hofmann, Stefan G., et al.
Publicado: (2015)

Neuroenhancement and the strength model of self-control
por: Englert, Chris, et al.
Publicado: (2015)

Can self-validating neuroenhancement be autonomous?
por: Varelius, Jukka
Publicado: (2019)

Just “Like Coffee” or Neuroenhancement by Stimulants?
por: Franke, Andreas G., et al.
Publicado: (2021)

Neuroenhancement: State of the Art and Future Perspectives
por: Marazziti, Donatella, et al.
Publicado: (2021)

Neuroenhancement of surgeons during robotic suturing
por: Patel, Ronak, et al.
Publicado: (2021)

Non-invasive brain stimulation and neuroenhancement
por: Antal, Andrea, et al.
Publicado: (2022)

New tools for neuroenhancement – what about neuroethics?
por: Erhardt, Julija, et al.
Publicado: (2016)

Portable and Wearable Brain Technologies for Neuroenhancement and Neurorehabilitation
por: Naseer, Noman, et al.
Publicado: (2018)

Bottom Up Ethics - Neuroenhancement in Education and Employment
por: Bard, Imre, et al.
Publicado: (2018)

The Role of Nitric Oxide in the Intraocular Pressure Lowering Efficacy of Latanoprostene Bunod: Review of Nonclinical Studies
por: Cavet, Megan E., et al.
Publicado: (2018)

Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art
por: Lambuk, Lidawani, et al.
Publicado: (2022)

Neuroprotective effects of total saponins from Rubus parvifolius L. on cerebral ischemia/reperfusion injury in rats☆
por: Wang, Jisheng, et al.
Publicado: (2012)

Biological Effects of Ciliary Neurotrophic Factor on hMADS Adipocytes
por: Perugini, Jessica, et al.
Publicado: (2019)

Effects of Yulangsan polysaccharide on monoamine neurotransmitters, adenylate cyclase activity and brain-derived neurotrophic factor expression in a mouse model of depression induced by unpredictable chronic mild stress☆
por: Liang, Shuang, et al.
Publicado: (2012)

Neuroenhancement with Vitamin B12—Underestimated Neurological Significance
por: Gröber, Uwe, et al.
Publicado: (2013)

The Complexity of Neuroenhancement and the Adoption of a Social Cognitive Perspective
por: Zelli, Arnaldo, et al.
Publicado: (2015)

Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement
por: Gahr, Maximilian, et al.
Publicado: (2017)

“Self-Neuroenhancement”: The Last Frontier of Noninvasive Brain Stimulation?
por: Fisicaro, Francesco, et al.
Publicado: (2020)

Psychiatric Comorbidity and Stress in Medical Students Using Neuroenhancers
por: Jebrini, Tarek, et al.
Publicado: (2021)

Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma☆
por: Mi, Xue-Song, et al.
Publicado: (2012)

The neurotrophic and neuroprotective effects of psychotropic agents
por: Hunsberger, Joshua, et al.
Publicado: (2009)

Neurotrophic and Neuroprotective Effects of Hericium erinaceus
por: Szućko-Kociuba, Izabela, et al.
Publicado: (2023)

Neuroenhancement and neuroprotection by oral solution citicoline in non-arteritic ischemic optic neuropathy as a model of neurodegeneration: A randomized pilot study
por: Parisi, Vincenzo, et al.
Publicado: (2019)

Expression of ciliary neurotrophic factor and its receptor in experimental obstructive nephropathy
por: Lee, Byoung-Seung, et al.
Publicado: (2011)

The trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat
por: Zhang, Yujun, et al.
Publicado: (2015)

Action of Administered Ciliary Neurotrophic Factor on the Mouse Dorsal Vagal Complex
por: Senzacqua, Martina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_q1k5vl285k4ofda750gdivhddm