Cargando…
Collagen for neural tissue engineering: Materials, strategies, and challenges
Neural tissue engineering (NTE) has made remarkable strides in recent years and holds great promise for treating several devastating neurological disorders. Selecting optimal scaffolding material is crucial for NET design strategies that enable neural and non-neural cell differentiation and axonal g...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183670/ https://www.ncbi.nlm.nih.gov/pubmed/37197743 http://dx.doi.org/10.1016/j.mtbio.2023.100639 |
_version_ | 1785042006509092864 |
---|---|
author | Huang, Wen-Hui Ding, Sheng-Long Zhao, Xi-Yuan Li, Kai Guo, Hai-Tao Zhang, Ming-Zhu Gu, Qi |
author_facet | Huang, Wen-Hui Ding, Sheng-Long Zhao, Xi-Yuan Li, Kai Guo, Hai-Tao Zhang, Ming-Zhu Gu, Qi |
author_sort | Huang, Wen-Hui |
collection | PubMed |
description | Neural tissue engineering (NTE) has made remarkable strides in recent years and holds great promise for treating several devastating neurological disorders. Selecting optimal scaffolding material is crucial for NET design strategies that enable neural and non-neural cell differentiation and axonal growth. Collagen is extensively employed in NTE applications due to the inherent resistance of the nervous system against regeneration, functionalized with neurotrophic factors, antagonists of neural growth inhibitors, and other neural growth-promoting agents. Recent advancements in integrating collagen with manufacturing strategies, such as scaffolding, electrospinning, and 3D bioprinting, provide localized trophic support, guide cell alignment, and protect neural cells from immune activity. This review categorises and analyses collagen-based processing techniques investigated for neural-specific applications, highlighting their strengths and weaknesses in repair, regeneration, and recovery. We also evaluate the potential prospects and challenges of using collagen-based biomaterials in NTE. Overall, this review offers a comprehensive and systematic framework for the rational evaluation and applications of collagen in NTE. |
format | Online Article Text |
id | pubmed-10183670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101836702023-05-16 Collagen for neural tissue engineering: Materials, strategies, and challenges Huang, Wen-Hui Ding, Sheng-Long Zhao, Xi-Yuan Li, Kai Guo, Hai-Tao Zhang, Ming-Zhu Gu, Qi Mater Today Bio Review Article Neural tissue engineering (NTE) has made remarkable strides in recent years and holds great promise for treating several devastating neurological disorders. Selecting optimal scaffolding material is crucial for NET design strategies that enable neural and non-neural cell differentiation and axonal growth. Collagen is extensively employed in NTE applications due to the inherent resistance of the nervous system against regeneration, functionalized with neurotrophic factors, antagonists of neural growth inhibitors, and other neural growth-promoting agents. Recent advancements in integrating collagen with manufacturing strategies, such as scaffolding, electrospinning, and 3D bioprinting, provide localized trophic support, guide cell alignment, and protect neural cells from immune activity. This review categorises and analyses collagen-based processing techniques investigated for neural-specific applications, highlighting their strengths and weaknesses in repair, regeneration, and recovery. We also evaluate the potential prospects and challenges of using collagen-based biomaterials in NTE. Overall, this review offers a comprehensive and systematic framework for the rational evaluation and applications of collagen in NTE. Elsevier 2023-05-02 /pmc/articles/PMC10183670/ /pubmed/37197743 http://dx.doi.org/10.1016/j.mtbio.2023.100639 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Huang, Wen-Hui Ding, Sheng-Long Zhao, Xi-Yuan Li, Kai Guo, Hai-Tao Zhang, Ming-Zhu Gu, Qi Collagen for neural tissue engineering: Materials, strategies, and challenges |
title | Collagen for neural tissue engineering: Materials, strategies, and challenges |
title_full | Collagen for neural tissue engineering: Materials, strategies, and challenges |
title_fullStr | Collagen for neural tissue engineering: Materials, strategies, and challenges |
title_full_unstemmed | Collagen for neural tissue engineering: Materials, strategies, and challenges |
title_short | Collagen for neural tissue engineering: Materials, strategies, and challenges |
title_sort | collagen for neural tissue engineering: materials, strategies, and challenges |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183670/ https://www.ncbi.nlm.nih.gov/pubmed/37197743 http://dx.doi.org/10.1016/j.mtbio.2023.100639 |
work_keys_str_mv | AT huangwenhui collagenforneuraltissueengineeringmaterialsstrategiesandchallenges AT dingshenglong collagenforneuraltissueengineeringmaterialsstrategiesandchallenges AT zhaoxiyuan collagenforneuraltissueengineeringmaterialsstrategiesandchallenges AT likai collagenforneuraltissueengineeringmaterialsstrategiesandchallenges AT guohaitao collagenforneuraltissueengineeringmaterialsstrategiesandchallenges AT zhangmingzhu collagenforneuraltissueengineeringmaterialsstrategiesandchallenges AT guqi collagenforneuraltissueengineeringmaterialsstrategiesandchallenges |