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Collagen for neural tissue engineering: Materials, strategies, and challenges

Neural tissue engineering (NTE) has made remarkable strides in recent years and holds great promise for treating several devastating neurological disorders. Selecting optimal scaffolding material is crucial for NET design strategies that enable neural and non-neural cell differentiation and axonal g...

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Detalles Bibliográficos
Autores principales: Huang, Wen-Hui, Ding, Sheng-Long, Zhao, Xi-Yuan, Li, Kai, Guo, Hai-Tao, Zhang, Ming-Zhu, Gu, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183670/
https://www.ncbi.nlm.nih.gov/pubmed/37197743
http://dx.doi.org/10.1016/j.mtbio.2023.100639
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author Huang, Wen-Hui
Ding, Sheng-Long
Zhao, Xi-Yuan
Li, Kai
Guo, Hai-Tao
Zhang, Ming-Zhu
Gu, Qi
author_facet Huang, Wen-Hui
Ding, Sheng-Long
Zhao, Xi-Yuan
Li, Kai
Guo, Hai-Tao
Zhang, Ming-Zhu
Gu, Qi
author_sort Huang, Wen-Hui
collection PubMed
description Neural tissue engineering (NTE) has made remarkable strides in recent years and holds great promise for treating several devastating neurological disorders. Selecting optimal scaffolding material is crucial for NET design strategies that enable neural and non-neural cell differentiation and axonal growth. Collagen is extensively employed in NTE applications due to the inherent resistance of the nervous system against regeneration, functionalized with neurotrophic factors, antagonists of neural growth inhibitors, and other neural growth-promoting agents. Recent advancements in integrating collagen with manufacturing strategies, such as scaffolding, electrospinning, and 3D bioprinting, provide localized trophic support, guide cell alignment, and protect neural cells from immune activity. This review categorises and analyses collagen-based processing techniques investigated for neural-specific applications, highlighting their strengths and weaknesses in repair, regeneration, and recovery. We also evaluate the potential prospects and challenges of using collagen-based biomaterials in NTE. Overall, this review offers a comprehensive and systematic framework for the rational evaluation and applications of collagen in NTE.
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spelling pubmed-101836702023-05-16 Collagen for neural tissue engineering: Materials, strategies, and challenges Huang, Wen-Hui Ding, Sheng-Long Zhao, Xi-Yuan Li, Kai Guo, Hai-Tao Zhang, Ming-Zhu Gu, Qi Mater Today Bio Review Article Neural tissue engineering (NTE) has made remarkable strides in recent years and holds great promise for treating several devastating neurological disorders. Selecting optimal scaffolding material is crucial for NET design strategies that enable neural and non-neural cell differentiation and axonal growth. Collagen is extensively employed in NTE applications due to the inherent resistance of the nervous system against regeneration, functionalized with neurotrophic factors, antagonists of neural growth inhibitors, and other neural growth-promoting agents. Recent advancements in integrating collagen with manufacturing strategies, such as scaffolding, electrospinning, and 3D bioprinting, provide localized trophic support, guide cell alignment, and protect neural cells from immune activity. This review categorises and analyses collagen-based processing techniques investigated for neural-specific applications, highlighting their strengths and weaknesses in repair, regeneration, and recovery. We also evaluate the potential prospects and challenges of using collagen-based biomaterials in NTE. Overall, this review offers a comprehensive and systematic framework for the rational evaluation and applications of collagen in NTE. Elsevier 2023-05-02 /pmc/articles/PMC10183670/ /pubmed/37197743 http://dx.doi.org/10.1016/j.mtbio.2023.100639 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Huang, Wen-Hui
Ding, Sheng-Long
Zhao, Xi-Yuan
Li, Kai
Guo, Hai-Tao
Zhang, Ming-Zhu
Gu, Qi
Collagen for neural tissue engineering: Materials, strategies, and challenges
title Collagen for neural tissue engineering: Materials, strategies, and challenges
title_full Collagen for neural tissue engineering: Materials, strategies, and challenges
title_fullStr Collagen for neural tissue engineering: Materials, strategies, and challenges
title_full_unstemmed Collagen for neural tissue engineering: Materials, strategies, and challenges
title_short Collagen for neural tissue engineering: Materials, strategies, and challenges
title_sort collagen for neural tissue engineering: materials, strategies, and challenges
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183670/
https://www.ncbi.nlm.nih.gov/pubmed/37197743
http://dx.doi.org/10.1016/j.mtbio.2023.100639
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