Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy

UFMylation involves the covalent modification of substrate proteins with UFM1 (Ubiquitin‐fold modifier 1) and is important for maintaining ER homeostasis. Stalled translation triggers the UFMylation of ER‐bound ribosomes and activates C53‐mediated autophagy to clear toxic polypeptides. C53 contains...

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Detalles Bibliográficos
Autores principales: Picchianti, Lorenzo, Sánchez de Medina Hernández, Víctor, Zhan, Ni, Irwin, Nicholas AT, Groh, Roan, Stephani, Madlen, Hornegger, Harald, Beveridge, Rebecca, Sawa‐Makarska, Justyna, Lendl, Thomas, Grujic, Nenad, Naumann, Christin, Martens, Sascha, Richards, Thomas A, Clausen, Tim, Ramundo, Silvia, Karagöz, G Elif, Dagdas, Yasin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183829/
https://www.ncbi.nlm.nih.gov/pubmed/36762703
http://dx.doi.org/10.15252/embj.2022112053

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