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Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles
Objective To establish a relationship between serum progesterone values on the day of frozen blastocyst transfer in hormone-replaced cycles with the probability of pregnancy, miscarriage or delivery. Methods This was an ambispective observational study including all frozen-thawed embryo transfer c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183892/ https://www.ncbi.nlm.nih.gov/pubmed/34547795 http://dx.doi.org/10.1055/s-0041-1735229 |
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author | Metello, José Tomás, Claudia Ferreira, Pedro Bravo, Iris Branquinho, MaryJo Santos-Ribeiro, Samuel |
author_facet | Metello, José Tomás, Claudia Ferreira, Pedro Bravo, Iris Branquinho, MaryJo Santos-Ribeiro, Samuel |
author_sort | Metello, José |
collection | PubMed |
description | Objective To establish a relationship between serum progesterone values on the day of frozen blastocyst transfer in hormone-replaced cycles with the probability of pregnancy, miscarriage or delivery. Methods This was an ambispective observational study including all frozen-thawed embryo transfer cycles performed at our department following in vitro fecundation from May 2018 to June 2019. The outcomes evaluated were β human chorionic gonadotropin (β-hCG)-positive pregnancy and delivery. Groups were compared according to the level of serum progesterone on the day of embryo transfer: the 1 (st) quartile of progesterone was compared against the other quartiles and then the 2 (nd) and 3 (rd) quartiles against the 4 (th) quartile. Results A total of 140 transfers were included in the analysis: 87 with β-HCG > 10 IU/L (62%), of which 50 (36%) delivered and 37 had a miscarriage (42%). Women with lower progesterone levels (< 10.7ng/mL) had a trend toward higher β-HCG-positive (72 versus 59%; p > 0.05), lower delivery (26 versus 39%; p > 0.05) and higher miscarriage rates (64 versus 33%; p < 0.01). Comparing the middle quartiles (P25–50) with those above percentiles 75, the rate of pregnancy was similar (60 versus 57%; p > 0.05), although there was a trend toward a higher number of deliveries (43 versus 31%; p > 0.05) and a lower number of miscarriages (28 versus 45%; p > 0.05). These differences were not statistically significant. Conclusion There were no differences in pregnancy and delivery rates related with the progesterone level when measured in the transfer day. The miscarriage rate was higher in the 1 (st) quartile group. |
format | Online Article Text |
id | pubmed-10183892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101838922023-07-27 Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles Metello, José Tomás, Claudia Ferreira, Pedro Bravo, Iris Branquinho, MaryJo Santos-Ribeiro, Samuel Rev Bras Ginecol Obstet Objective To establish a relationship between serum progesterone values on the day of frozen blastocyst transfer in hormone-replaced cycles with the probability of pregnancy, miscarriage or delivery. Methods This was an ambispective observational study including all frozen-thawed embryo transfer cycles performed at our department following in vitro fecundation from May 2018 to June 2019. The outcomes evaluated were β human chorionic gonadotropin (β-hCG)-positive pregnancy and delivery. Groups were compared according to the level of serum progesterone on the day of embryo transfer: the 1 (st) quartile of progesterone was compared against the other quartiles and then the 2 (nd) and 3 (rd) quartiles against the 4 (th) quartile. Results A total of 140 transfers were included in the analysis: 87 with β-HCG > 10 IU/L (62%), of which 50 (36%) delivered and 37 had a miscarriage (42%). Women with lower progesterone levels (< 10.7ng/mL) had a trend toward higher β-HCG-positive (72 versus 59%; p > 0.05), lower delivery (26 versus 39%; p > 0.05) and higher miscarriage rates (64 versus 33%; p < 0.01). Comparing the middle quartiles (P25–50) with those above percentiles 75, the rate of pregnancy was similar (60 versus 57%; p > 0.05), although there was a trend toward a higher number of deliveries (43 versus 31%; p > 0.05) and a lower number of miscarriages (28 versus 45%; p > 0.05). These differences were not statistically significant. Conclusion There were no differences in pregnancy and delivery rates related with the progesterone level when measured in the transfer day. The miscarriage rate was higher in the 1 (st) quartile group. Thieme Revinter Publicações Ltda. 2021-09-21 /pmc/articles/PMC10183892/ /pubmed/34547795 http://dx.doi.org/10.1055/s-0041-1735229 Text en Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Metello, José Tomás, Claudia Ferreira, Pedro Bravo, Iris Branquinho, MaryJo Santos-Ribeiro, Samuel Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles |
title | Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles |
title_full | Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles |
title_fullStr | Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles |
title_full_unstemmed | Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles |
title_short | Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles |
title_sort | impact of plasmatic progesterone on the day of frozen embryo transfer in hormone-induced cycles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183892/ https://www.ncbi.nlm.nih.gov/pubmed/34547795 http://dx.doi.org/10.1055/s-0041-1735229 |
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