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Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study
Objective To evaluate the number of patients with early-stage breast cancer who could benefit from the omission of axillary surgery following the application of the Alliance for Clinical Trials in Oncology (ACOSOG) Z0011 trial criteria. Methods A retrospective cohort study conducted in the Hospita...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183926/ https://www.ncbi.nlm.nih.gov/pubmed/33784760 http://dx.doi.org/10.1055/s-0041-1725052 |
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author | Shinzato, Julia Yoriko Serra, Katia Piton Eugeni, Caroline Cabello, Cesar Cardoso-Filho, Cassio Zeferino, Luís Carlos |
author_facet | Shinzato, Julia Yoriko Serra, Katia Piton Eugeni, Caroline Cabello, Cesar Cardoso-Filho, Cassio Zeferino, Luís Carlos |
author_sort | Shinzato, Julia Yoriko |
collection | PubMed |
description | Objective To evaluate the number of patients with early-stage breast cancer who could benefit from the omission of axillary surgery following the application of the Alliance for Clinical Trials in Oncology (ACOSOG) Z0011 trial criteria. Methods A retrospective cohort study conducted in the Hospital da Mulher da Universidade Estadual de Campinas. The study population included 384 women diagnosed with early-stage invasive breast cancer, clinically negative axilla, treated with breast-conserving surgery and sentinel lymph node biopsy, radiation therapy, chemotherapy and/or endocrine therapy, from January 2005 to December 2010. The ACOSOG Z0011 trial criteria were applied to this population and a statistical analysis was performed to make a comparison between populations. Results A total of 384 patients underwent breast-conserving surgery and sentinel lymph node biopsy. Of the total number of patients, 86 women underwent axillary lymph node dissection for metastatic sentinel lymph nodes (SNLs). One patient underwent axillary node dissection due to a suspicious SLN intraoperatively, thus, she was excluded from the study. Among these patients, 82/86 (95.3%) had one to two involved sentinel lymph nodes and met the criteria for the ACOSOG Z0011 trial with the omission of axillary lymph node dissection. Among the 82 eligible women, there were only 13 cases (15.9%) of lymphovascular invasion and 62 cases (75.6%) of tumors measuring up to 2 cm in diameter (T1). Conclusion The ACOSOG Z0011 trial criteria can be applied to a select group of SLN-positive patients, reducing the costs and morbidities of breast cancer surgery. |
format | Online Article Text |
id | pubmed-10183926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101839262023-07-27 Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study Shinzato, Julia Yoriko Serra, Katia Piton Eugeni, Caroline Cabello, Cesar Cardoso-Filho, Cassio Zeferino, Luís Carlos Rev Bras Ginecol Obstet Objective To evaluate the number of patients with early-stage breast cancer who could benefit from the omission of axillary surgery following the application of the Alliance for Clinical Trials in Oncology (ACOSOG) Z0011 trial criteria. Methods A retrospective cohort study conducted in the Hospital da Mulher da Universidade Estadual de Campinas. The study population included 384 women diagnosed with early-stage invasive breast cancer, clinically negative axilla, treated with breast-conserving surgery and sentinel lymph node biopsy, radiation therapy, chemotherapy and/or endocrine therapy, from January 2005 to December 2010. The ACOSOG Z0011 trial criteria were applied to this population and a statistical analysis was performed to make a comparison between populations. Results A total of 384 patients underwent breast-conserving surgery and sentinel lymph node biopsy. Of the total number of patients, 86 women underwent axillary lymph node dissection for metastatic sentinel lymph nodes (SNLs). One patient underwent axillary node dissection due to a suspicious SLN intraoperatively, thus, she was excluded from the study. Among these patients, 82/86 (95.3%) had one to two involved sentinel lymph nodes and met the criteria for the ACOSOG Z0011 trial with the omission of axillary lymph node dissection. Among the 82 eligible women, there were only 13 cases (15.9%) of lymphovascular invasion and 62 cases (75.6%) of tumors measuring up to 2 cm in diameter (T1). Conclusion The ACOSOG Z0011 trial criteria can be applied to a select group of SLN-positive patients, reducing the costs and morbidities of breast cancer surgery. Thieme Revinter Publicações Ltda. 2021-03-30 /pmc/articles/PMC10183926/ /pubmed/33784760 http://dx.doi.org/10.1055/s-0041-1725052 Text en Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Shinzato, Julia Yoriko Serra, Katia Piton Eugeni, Caroline Cabello, Cesar Cardoso-Filho, Cassio Zeferino, Luís Carlos Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study |
title | Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study |
title_full | Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study |
title_fullStr | Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study |
title_full_unstemmed | Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study |
title_short | Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study |
title_sort | potential impact of the z0011 trial on the omission of axillary dissection: a retrospective cohort study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183926/ https://www.ncbi.nlm.nih.gov/pubmed/33784760 http://dx.doi.org/10.1055/s-0041-1725052 |
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