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NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors

Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting osteoclast differentiation has proven to be an effective strategy. Here, we revealed that osteoclast precursors (pre-OCs) were more susceptible to thioredoxin reductase 1 (TXNRD1) inhibitors than bone marrow-derived...

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Detalles Bibliográficos
Autores principales:	Zhong, Zeyuan, Zhang, Chongjing, Ni, Shuo, Ma, Miao, Zhang, Xiaomeng, Sang, Weicong, Lv, Tao, Qian, Zhi, Yi, Chengqing, Yu, Baoqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184050/ https://www.ncbi.nlm.nih.gov/pubmed/37148740 http://dx.doi.org/10.1016/j.redox.2023.102711

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