Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation

Malignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP). However, the mechanism underlying local AP activation is not fully understood. We hypothesized that complement factor D (CFD) secreted by endothelial cells...

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Detalles Bibliográficos
Autores principales: Wang, Zheng, Zhang, Zhe, Li, Yuan, Zhang, Ying, Wei, Min, Li, Hui, Yang, Shanzhi, Zhou, Yali, Zhou, Xinjin, Xing, Guolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184087/
https://www.ncbi.nlm.nih.gov/pubmed/37188751
http://dx.doi.org/10.1038/s41440-023-01300-3

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