Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia

[Image: see text] The accumulation of lipids in cardiomyocytes contributes to cardiac dysfunction. The specific blockage of cardiomyocyte cholesteryl ester (CE) loading by antibodies (Abs) against the P3 sequence (Gly(1127)–Cys(1140)) of the LRP1 receptor improves cardiac insulin sensitivity. The im...

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Detalles Bibliográficos
Autores principales: Samouillan, Valerie, Garcia, Eduardo, Benitez-Amaro, Aleyda, La Chica Lhoëst, Maria Teresa, Dandurand, Jany, Actis Dato, Virginia, Guerra, Jose Maria, Escolà-Gil, Joan Carles, Chiabrando, Gustavo, Enrich, Carlos, Llorente-Cortes, Vicenta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184115/
https://www.ncbi.nlm.nih.gov/pubmed/37116069
http://dx.doi.org/10.1021/acs.jmedchem.2c02103

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