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Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening

[Image: see text] Combinatorial library screening increasingly explores chemical space beyond the Ro5 (bRo5), which is useful for investigating ”undruggable” targets but suffers compromised cellular permeability and therefore bioavailability. Moreover, structure–permeation relationships for bRo5 mol...

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Detalles Bibliográficos
Autores principales:	Hu, Juan, Chan, Alix I, Adaligil, Emel, Kekessie, Ivy, Takahashi, Mifune, Song, Aimin, Cunningham, Christian N., Paegel, Brian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184116/ https://www.ncbi.nlm.nih.gov/pubmed/37075027 http://dx.doi.org/10.1021/acs.jmedchem.3c00138

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