Lenalidomide Stabilizes Protein–Protein Complexes by Turning Labile Intermolecular H-Bonds into Robust Interactions

[Image: see text] Targeted protein degradation is a promising therapeutic strategy, spearheaded by the anti-myeloma drugs lenalidomide and pomalidomide. These drugs stabilize very efficiently the complex between the E3 ligase Cereblon (CRBN) and several non-native client proteins (neo-substrates), i...

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Detalles Bibliográficos
Autores principales: Miñarro-Lleonar, Marina, Bertran-Mostazo, Andrea, Duro, Jorge, Barril, Xavier, Juárez-Jiménez, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184122/
https://www.ncbi.nlm.nih.gov/pubmed/37083375
http://dx.doi.org/10.1021/acs.jmedchem.2c01692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184122/
https://www.ncbi.nlm.nih.gov/pubmed/37083375
http://dx.doi.org/10.1021/acs.jmedchem.2c01692

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