Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer’s Disease Mouse Model

[Image: see text] We present the synthesis and characterization of merged human butyrylcholinesterase (hBChE) inhibitor/cannabinoid receptor 2 (hCB(2)R) ligands for the treatment of neurodegeneration. In total, 15 benzimidazole carbamates were synthesized and tested for their inhibition of human cho...

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Detalles Bibliográficos
Autores principales: Spatz, Philipp, Steinmüller, Sophie A. M., Tutov, Anna, Poeta, Eleonora, Morilleau, Axelle, Carles, Allison, Deventer, Marie H., Hofmann, Julian, Stove, Christophe P., Monti, Barbara, Maurice, Tangui, Decker, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184129/
https://www.ncbi.nlm.nih.gov/pubmed/37127287
http://dx.doi.org/10.1021/acs.jmedchem.3c00541

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