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ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool
The term “reactive oxygen species” (ROS) refers to a family of extremely reactive molecules. They are crucial as secondary messengers in both physiological functioning and the development of cancer. Tumors have developed the ability to survive at elevated ROS levels with significantly higher H(2)O(2...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184222/ https://www.ncbi.nlm.nih.gov/pubmed/35524662 http://dx.doi.org/10.2174/2667387816666220506203123 |
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author | Newton Amaldoss, Maria John Sorrell, Charles Christopher |
author_facet | Newton Amaldoss, Maria John Sorrell, Charles Christopher |
author_sort | Newton Amaldoss, Maria John |
collection | PubMed |
description | The term “reactive oxygen species” (ROS) refers to a family of extremely reactive molecules. They are crucial as secondary messengers in both physiological functioning and the development of cancer. Tumors have developed the ability to survive at elevated ROS levels with significantly higher H(2)O(2) levels than normal tissues. Chemodynamic therapy is a novel approach to cancer treatment that generates highly toxic hydroxyl radicals via a Fenton/Fenton-like reaction between metals and peroxides. Inorganic nanoparticles cause cytotoxicity by releasing ROS. Inorganic nanoparticles can alter redox homoeostasis by generating ROS or diminishing scavenging mechanisms. Internalized nanoparticles generate ROS in biological systems independent of the route of internalisation. This method of producing ROS could be employed to kill cancer cells as a therapeutic strategy. ROS also play a role in regulating the development of normal stem cells, as excessive ROS disturb the stem cells' regular biological cycles. ROS treatment has a significant effect on normal cellular function. Mitochondrial ROS are at the centre of metabolic changes and control a variety of other cellular processes, which can lead to medication resistance in cancer patients. As a result, utilising ROS in therapeutic applications can be a double-edged sword that requires better understanding. |
format | Online Article Text |
id | pubmed-10184222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-101842222023-05-16 ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool Newton Amaldoss, Maria John Sorrell, Charles Christopher Recent Adv Drug Deliv Formul Drug Delivery The term “reactive oxygen species” (ROS) refers to a family of extremely reactive molecules. They are crucial as secondary messengers in both physiological functioning and the development of cancer. Tumors have developed the ability to survive at elevated ROS levels with significantly higher H(2)O(2) levels than normal tissues. Chemodynamic therapy is a novel approach to cancer treatment that generates highly toxic hydroxyl radicals via a Fenton/Fenton-like reaction between metals and peroxides. Inorganic nanoparticles cause cytotoxicity by releasing ROS. Inorganic nanoparticles can alter redox homoeostasis by generating ROS or diminishing scavenging mechanisms. Internalized nanoparticles generate ROS in biological systems independent of the route of internalisation. This method of producing ROS could be employed to kill cancer cells as a therapeutic strategy. ROS also play a role in regulating the development of normal stem cells, as excessive ROS disturb the stem cells' regular biological cycles. ROS treatment has a significant effect on normal cellular function. Mitochondrial ROS are at the centre of metabolic changes and control a variety of other cellular processes, which can lead to medication resistance in cancer patients. As a result, utilising ROS in therapeutic applications can be a double-edged sword that requires better understanding. Bentham Science Publishers 2022-10-19 2022-10-19 /pmc/articles/PMC10184222/ /pubmed/35524662 http://dx.doi.org/10.2174/2667387816666220506203123 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode |
spellingShingle | Drug Delivery Newton Amaldoss, Maria John Sorrell, Charles Christopher ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool |
title | ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool |
title_full | ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool |
title_fullStr | ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool |
title_full_unstemmed | ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool |
title_short | ROS Modulating Inorganic Nanoparticles: A Novel Cancer Therapeutic Tool |
title_sort | ros modulating inorganic nanoparticles: a novel cancer therapeutic tool |
topic | Drug Delivery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184222/ https://www.ncbi.nlm.nih.gov/pubmed/35524662 http://dx.doi.org/10.2174/2667387816666220506203123 |
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