ERβ in Granulosa Cell Tumors and Its Clinical Potential

Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCTs, the tumor type is largely understudied and lac...

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Autores principales: Birgersson, Madeleine, Indukuri, Rajitha, Antonson, Per, Nalvarte, Ivan, Archer, Amena, Williams, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184458/
https://www.ncbi.nlm.nih.gov/pubmed/37075218
http://dx.doi.org/10.1210/endocr/bqad063
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author Birgersson, Madeleine
Indukuri, Rajitha
Antonson, Per
Nalvarte, Ivan
Archer, Amena
Williams, Cecilia
author_facet Birgersson, Madeleine
Indukuri, Rajitha
Antonson, Per
Nalvarte, Ivan
Archer, Amena
Williams, Cecilia
author_sort Birgersson, Madeleine
collection PubMed
description Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCTs, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCTs, which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCTs is not known. In this review, we summarize the current knowledge about the action of ERβ in the ovary and discuss its prospective role in GCTs.
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spelling pubmed-101844582023-05-16 ERβ in Granulosa Cell Tumors and Its Clinical Potential Birgersson, Madeleine Indukuri, Rajitha Antonson, Per Nalvarte, Ivan Archer, Amena Williams, Cecilia Endocrinology Mini-Review Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCTs, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCTs, which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCTs is not known. In this review, we summarize the current knowledge about the action of ERβ in the ovary and discuss its prospective role in GCTs. Oxford University Press 2023-04-19 /pmc/articles/PMC10184458/ /pubmed/37075218 http://dx.doi.org/10.1210/endocr/bqad063 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Mini-Review
Birgersson, Madeleine
Indukuri, Rajitha
Antonson, Per
Nalvarte, Ivan
Archer, Amena
Williams, Cecilia
ERβ in Granulosa Cell Tumors and Its Clinical Potential
title ERβ in Granulosa Cell Tumors and Its Clinical Potential
title_full ERβ in Granulosa Cell Tumors and Its Clinical Potential
title_fullStr ERβ in Granulosa Cell Tumors and Its Clinical Potential
title_full_unstemmed ERβ in Granulosa Cell Tumors and Its Clinical Potential
title_short ERβ in Granulosa Cell Tumors and Its Clinical Potential
title_sort erβ in granulosa cell tumors and its clinical potential
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184458/
https://www.ncbi.nlm.nih.gov/pubmed/37075218
http://dx.doi.org/10.1210/endocr/bqad063
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