An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-coronavirus Fusion Inhibitor with Strong Blood–Brain Barrier Permeability, Long Half-Life, and Promising Oral Bioavailability

[Image: see text] Neutralizing antibodies and fusion inhibitory peptides have the potential required to combat the global pandemic caused by SARS-CoV-2 and its variants. However, the lack of oral bioavailability and enzymatic susceptibility limited their application, necessitating the development of...

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Autores principales: Xue, Songyi, Xu, Wei, Wang, Lei, Wang, Xinling, Duan, Qianyu, Calcul, Laurent, Wang, Shaohui, Liu, Wenqi, Sun, Xingmin, Lu, Lu, Jiang, Shibo, Cai, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184535/
https://www.ncbi.nlm.nih.gov/pubmed/37252367
http://dx.doi.org/10.1021/acscentsci.3c00313

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