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Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease
INTRODUCTION: Blood bone metabolic biomarkers are noninvasive indices for evaluating metabolic bone diseases. We investigated the relationships between blood bone metabolic biomarkers and anemia in chronic kidney disease (CKD) patients and analyzed the effects of parathyroidectomy (PTX) on the above...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184590/ https://www.ncbi.nlm.nih.gov/pubmed/37170583 http://dx.doi.org/10.1080/0886022X.2023.2210227 |
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author | Li, Fan Ye, Xiaoxue Yang, Guang Huang, Hui Bian, Anning Xing, Changying Tang, Shaowen Zhang, Jing Jiang, Yao Chen, Huimin Yin, Caixia Zhang, Lina Wang, Jing Huang, Yaoyu Zhou, Wenbin Wan, Huiting Zha, Xiaoming Zeng, Ming Wang, Ningning |
author_facet | Li, Fan Ye, Xiaoxue Yang, Guang Huang, Hui Bian, Anning Xing, Changying Tang, Shaowen Zhang, Jing Jiang, Yao Chen, Huimin Yin, Caixia Zhang, Lina Wang, Jing Huang, Yaoyu Zhou, Wenbin Wan, Huiting Zha, Xiaoming Zeng, Ming Wang, Ningning |
author_sort | Li, Fan |
collection | PubMed |
description | INTRODUCTION: Blood bone metabolic biomarkers are noninvasive indices for evaluating metabolic bone diseases. We investigated the relationships between blood bone metabolic biomarkers and anemia in chronic kidney disease (CKD) patients and analyzed the effects of parathyroidectomy (PTX) on the above indices. METHODS: In this cross-sectional study, 100 healthy controls and 239 CKD patients, including 46 secondary hyperparathyroidism (SHPT) patients with PTX, were enrolled. Moreover, a prospective study was conducted in which 28 PTX patients were followed up. The degree of anemia was classified as mild, moderate, or severe based on the tertiles of hemoglobin (Hb) levels of the anemic CKD patients, with cutoff values of 83 g/L and 102 g/L. Bone metabolic biomarkers, including calcium (Ca), phosphorus (P), intact parathyroid hormone (iPTH), fibroblast growth factor 23 (FGF23), and α-klotho, were tested. RESULTS: The mean estimated glomerular filtration rate (eGFR) in CKD patients was 25.7 ± 36.0 ml/min/1.73 m(2), and 84.10% of CKD patients had anemia. The baseline Hb levels in the mild, moderate, and severe anemia subgroups were 110.86 ± 5.99 g/L, 92.71 ± 5.96 g/L, and 67.38 ± 10.56 g/L, respectively. CKD patients had higher adjusted Ca, P, alkaline phosphatase (ALP), iPTH, and FGF23 levels and lower α-klotho levels than controls. Baseline adjusted Ca, P, iPTH, and α-klotho levels were associated with Hb levels in CKD patients. Blood adjusted Ca, P, and iPTH levels were correlated with anemia severity. After PTX (median interval: 6.88 months), anemia and high blood adjusted Ca, P, iPTH, and FGF23 levels were ameliorated, while α-klotho levels were increased. CONCLUSIONS: Blood adjusted Ca, P, iPTH, and α-klotho levels were correlated with Hb levels in CKD patients. Correction of bone metabolic disorders may be a therapeutic strategy for anemia treatment. |
format | Online Article Text |
id | pubmed-10184590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-101845902023-05-16 Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease Li, Fan Ye, Xiaoxue Yang, Guang Huang, Hui Bian, Anning Xing, Changying Tang, Shaowen Zhang, Jing Jiang, Yao Chen, Huimin Yin, Caixia Zhang, Lina Wang, Jing Huang, Yaoyu Zhou, Wenbin Wan, Huiting Zha, Xiaoming Zeng, Ming Wang, Ningning Ren Fail Clinical Study INTRODUCTION: Blood bone metabolic biomarkers are noninvasive indices for evaluating metabolic bone diseases. We investigated the relationships between blood bone metabolic biomarkers and anemia in chronic kidney disease (CKD) patients and analyzed the effects of parathyroidectomy (PTX) on the above indices. METHODS: In this cross-sectional study, 100 healthy controls and 239 CKD patients, including 46 secondary hyperparathyroidism (SHPT) patients with PTX, were enrolled. Moreover, a prospective study was conducted in which 28 PTX patients were followed up. The degree of anemia was classified as mild, moderate, or severe based on the tertiles of hemoglobin (Hb) levels of the anemic CKD patients, with cutoff values of 83 g/L and 102 g/L. Bone metabolic biomarkers, including calcium (Ca), phosphorus (P), intact parathyroid hormone (iPTH), fibroblast growth factor 23 (FGF23), and α-klotho, were tested. RESULTS: The mean estimated glomerular filtration rate (eGFR) in CKD patients was 25.7 ± 36.0 ml/min/1.73 m(2), and 84.10% of CKD patients had anemia. The baseline Hb levels in the mild, moderate, and severe anemia subgroups were 110.86 ± 5.99 g/L, 92.71 ± 5.96 g/L, and 67.38 ± 10.56 g/L, respectively. CKD patients had higher adjusted Ca, P, alkaline phosphatase (ALP), iPTH, and FGF23 levels and lower α-klotho levels than controls. Baseline adjusted Ca, P, iPTH, and α-klotho levels were associated with Hb levels in CKD patients. Blood adjusted Ca, P, and iPTH levels were correlated with anemia severity. After PTX (median interval: 6.88 months), anemia and high blood adjusted Ca, P, iPTH, and FGF23 levels were ameliorated, while α-klotho levels were increased. CONCLUSIONS: Blood adjusted Ca, P, iPTH, and α-klotho levels were correlated with Hb levels in CKD patients. Correction of bone metabolic disorders may be a therapeutic strategy for anemia treatment. Taylor & Francis 2023-05-12 /pmc/articles/PMC10184590/ /pubmed/37170583 http://dx.doi.org/10.1080/0886022X.2023.2210227 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Clinical Study Li, Fan Ye, Xiaoxue Yang, Guang Huang, Hui Bian, Anning Xing, Changying Tang, Shaowen Zhang, Jing Jiang, Yao Chen, Huimin Yin, Caixia Zhang, Lina Wang, Jing Huang, Yaoyu Zhou, Wenbin Wan, Huiting Zha, Xiaoming Zeng, Ming Wang, Ningning Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease |
title | Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease |
title_full | Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease |
title_fullStr | Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease |
title_full_unstemmed | Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease |
title_short | Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease |
title_sort | relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184590/ https://www.ncbi.nlm.nih.gov/pubmed/37170583 http://dx.doi.org/10.1080/0886022X.2023.2210227 |
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