Cargando…
Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol
[Image: see text] The cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) undergo extensive oxidative metabolism in the liver. Although cytochromes P450 form the primary, pharmacologically active, hydroxylated metabolites of CBD and THC, less is known about the enzymes that generat...
Autores principales: | Beers, Jessica L., Authement, Aurora K., Isoherranen, Nina, Jackson, Klarissa D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184666/ https://www.ncbi.nlm.nih.gov/pubmed/37197460 http://dx.doi.org/10.1021/acsmedchemlett.3c00017 |
Ejemplares similares
-
Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic modeling
por: Yeung, Cindy H. T., et al.
Publicado: (2023) -
Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites
por: Coca-Ruíz, Víctor, et al.
Publicado: (2022) -
Role of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors
por: Jackson, Klarissa D., et al.
Publicado: (2018) -
11-Nor-9-Carboxy Tetrahydrocannabinol Distribution in Fluid from the Chest Cavity in Cannabis-Related Post-Mortem Cases
por: Zughaibi, Torki A., et al.
Publicado: (2023) -
Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB(1)) Are Neither Obese Nor Diabetic
por: Marcus, David J., et al.
Publicado: (2016)