Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation

Dedicator of cytokinesis 3 (DOCK3) is an atypical member of the guanine nucleotide exchange factors (GEFs) and plays important roles in neurite outgrowth. DOCK3 forms a complex with Engulfment and cell motility protein 1 (Elmo1) and effectively activates Rac1 and actin dynamics. In this study, we sc...

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Detalles Bibliográficos
Autores principales: Namekata, Kazuhiko, Tsuji, Naoki, Guo, Xiaoli, Nishijima, Euido, Honda, Sari, Kitamura, Yuta, Yamasaki, Atsushi, Kishida, Masamichi, Takeyama, Jun, Ishikawa, Hirokazu, Shinozaki, Youichi, Kimura, Atsuko, Harada, Chikako, Harada, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184973/
https://www.ncbi.nlm.nih.gov/pubmed/37188749
http://dx.doi.org/10.1038/s41420-023-01460-8

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