Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-deficient cells. In contrast, here we show that inhi...

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Detalles Bibliográficos
Autores principales: Martino, Julieta, Siri, Sebastián Omar, Calzetta, Nicolás Luis, Paviolo, Natalia Soledad, Garro, Cintia, Pansa, Maria F, Carbajosa, Sofía, Brown, Aaron C, Bocco, José Luis, Gloger, Israel, Drewes, Gerard, Madauss, Kevin P, Soria, Gastón, Gottifredi, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185344/
https://www.ncbi.nlm.nih.gov/pubmed/37073955
http://dx.doi.org/10.7554/eLife.80254

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