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Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential

Tannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, these are the second most abundant polyphenols found in almost every plant part like stem, bark, fruit,...

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Autores principales: Rippin, Beniwal, Vikas, Sharma, Ajay, Singh, Bikram Jit, Ramniwas, Seema, Sak, Katrin, Kumar, Satish, Sharma, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185439/
https://www.ncbi.nlm.nih.gov/pubmed/37205316
http://dx.doi.org/10.37349/etat.2023.00129
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author Rippin,
Beniwal, Vikas
Sharma, Ajay
Singh, Bikram Jit
Ramniwas, Seema
Sak, Katrin
Kumar, Satish
Sharma, Anil K.
author_facet Rippin,
Beniwal, Vikas
Sharma, Ajay
Singh, Bikram Jit
Ramniwas, Seema
Sak, Katrin
Kumar, Satish
Sharma, Anil K.
author_sort Rippin,
collection PubMed
description Tannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, these are the second most abundant polyphenols found in almost every plant part like stem, bark, fruit, seed, leaves, etc. Depending upon their structural composition, these polyphenols can be divided into two distinct groups, namely condensed tannins and hydrolysable tannins. Hydrolysable tannins can be further divided into two types: gallotannins and ellagitannins. Gallotannins are formed by the esterification of D-glucose hydroxyl groups with gallic acid. The gallolyl moieties are bound by a depside bond. The current review focuses mainly on the anti-carcinogenic potential of recently discovered gallotannins, ginnalin A, and hamamelitannin (HAM). Both of these gallotannins possess two galloyl moieties linked to a core monosaccharide having anti-oxidant, anti-inflammatory, and anti-carcinogenic abilities. Ginnalin A is found in plants of the genus Acer whereas HAM is present in witch hazel plants. The biosynthetic pathway of ginnalin A along with the mechanism of the anti-cancer therapeutic potential of ginnalin A and HAM has been discussed. This review will certainly help researchers to work further on the chemo-therapeutic abilities of these two unique gallotannins.
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spelling pubmed-101854392023-05-17 Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential Rippin, Beniwal, Vikas Sharma, Ajay Singh, Bikram Jit Ramniwas, Seema Sak, Katrin Kumar, Satish Sharma, Anil K. Explor Target Antitumor Ther Review Tannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, these are the second most abundant polyphenols found in almost every plant part like stem, bark, fruit, seed, leaves, etc. Depending upon their structural composition, these polyphenols can be divided into two distinct groups, namely condensed tannins and hydrolysable tannins. Hydrolysable tannins can be further divided into two types: gallotannins and ellagitannins. Gallotannins are formed by the esterification of D-glucose hydroxyl groups with gallic acid. The gallolyl moieties are bound by a depside bond. The current review focuses mainly on the anti-carcinogenic potential of recently discovered gallotannins, ginnalin A, and hamamelitannin (HAM). Both of these gallotannins possess two galloyl moieties linked to a core monosaccharide having anti-oxidant, anti-inflammatory, and anti-carcinogenic abilities. Ginnalin A is found in plants of the genus Acer whereas HAM is present in witch hazel plants. The biosynthetic pathway of ginnalin A along with the mechanism of the anti-cancer therapeutic potential of ginnalin A and HAM has been discussed. This review will certainly help researchers to work further on the chemo-therapeutic abilities of these two unique gallotannins. Open Exploration 2023 2023-04-21 /pmc/articles/PMC10185439/ /pubmed/37205316 http://dx.doi.org/10.37349/etat.2023.00129 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Rippin,
Beniwal, Vikas
Sharma, Ajay
Singh, Bikram Jit
Ramniwas, Seema
Sak, Katrin
Kumar, Satish
Sharma, Anil K.
Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
title Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
title_full Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
title_fullStr Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
title_full_unstemmed Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
title_short Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
title_sort ginnalin a and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185439/
https://www.ncbi.nlm.nih.gov/pubmed/37205316
http://dx.doi.org/10.37349/etat.2023.00129
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