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Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy

Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. I...

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Autores principales: Chan, Max Kam-Kwan, Chan, Emily Lok-Yiu, Ji, Zoey Zeyuan, Chan, Alex Siu-Wing, Li, Chunjie, Leung, Kam-Tong, To, Ka-Fai, Tang, Patrick Ming-Kuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185444/
https://www.ncbi.nlm.nih.gov/pubmed/37205317
http://dx.doi.org/10.37349/etat.2023.00137
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author Chan, Max Kam-Kwan
Chan, Emily Lok-Yiu
Ji, Zoey Zeyuan
Chan, Alex Siu-Wing
Li, Chunjie
Leung, Kam-Tong
To, Ka-Fai
Tang, Patrick Ming-Kuen
author_facet Chan, Max Kam-Kwan
Chan, Emily Lok-Yiu
Ji, Zoey Zeyuan
Chan, Alex Siu-Wing
Li, Chunjie
Leung, Kam-Tong
To, Ka-Fai
Tang, Patrick Ming-Kuen
author_sort Chan, Max Kam-Kwan
collection PubMed
description Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. Interestingly, increasing evidence suggests that TGF-β enhances disease progression and drug resistance via immune-modulatory actions in the tumor microenvironment (TME) of solid tumors. A better understanding of its regulatory mechanisms in the TME at the molecular level can facilitate the development of precision medicine to block the protumoral actions of TGF-β in the TME. Here, the latest information about the regulatory mechanisms and translational research of TGF-β signaling in the TME for therapeutic development had been summarized.
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spelling pubmed-101854442023-05-17 Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy Chan, Max Kam-Kwan Chan, Emily Lok-Yiu Ji, Zoey Zeyuan Chan, Alex Siu-Wing Li, Chunjie Leung, Kam-Tong To, Ka-Fai Tang, Patrick Ming-Kuen Explor Target Antitumor Ther Review Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. Interestingly, increasing evidence suggests that TGF-β enhances disease progression and drug resistance via immune-modulatory actions in the tumor microenvironment (TME) of solid tumors. A better understanding of its regulatory mechanisms in the TME at the molecular level can facilitate the development of precision medicine to block the protumoral actions of TGF-β in the TME. Here, the latest information about the regulatory mechanisms and translational research of TGF-β signaling in the TME for therapeutic development had been summarized. Open Exploration 2023 2023-04-28 /pmc/articles/PMC10185444/ /pubmed/37205317 http://dx.doi.org/10.37349/etat.2023.00137 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Chan, Max Kam-Kwan
Chan, Emily Lok-Yiu
Ji, Zoey Zeyuan
Chan, Alex Siu-Wing
Li, Chunjie
Leung, Kam-Tong
To, Ka-Fai
Tang, Patrick Ming-Kuen
Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
title Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
title_full Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
title_fullStr Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
title_full_unstemmed Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
title_short Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
title_sort transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185444/
https://www.ncbi.nlm.nih.gov/pubmed/37205317
http://dx.doi.org/10.37349/etat.2023.00137
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