Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established. Here, we reported that ferroptosis represents a part of the chemotherapeutic drug etoposide-induced cel...

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Detalles Bibliográficos
Autores principales: Cheng, Feng, Dou, Jintao, Yang, Yi, Sun, Shaojie, Chen, Ruiqi, Zhang, Zhijian, Wei, Huijun, Li, Jianhui, Wu, Zhihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185500/
https://www.ncbi.nlm.nih.gov/pubmed/37188685
http://dx.doi.org/10.1038/s41420-023-01463-5

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