Synthesis, in vitro inhibitor screening, structure–activity relationship, and molecular dynamic simulation studies of novel thioquinoline derivatives as potent α-glucosidase inhibitors

New series of thioquinoline structures bearing phenylacetamide 9a–p were designed, synthesized and the structure of all derivatives was confirmed using different spectroscopic techniques including FTIR, (1)H-NMR, (13)C-NMR, ESI–MS and elemental analysis. Next, the α-glucosidase inhibitory activities...

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Detalles Bibliográficos
Autores principales: Forozan, RasaDokht, Ghomi, Minoo Khalili, Iraji, Aida, Montazer, Mohammad Nazari, Noori, Milad, Dastyafteh, Navid, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Sadat-Ebrahimi, Seyed Esmaeil, Larijani, Bagher, Javanshir, Shahrzad, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185516/
https://www.ncbi.nlm.nih.gov/pubmed/37188744
http://dx.doi.org/10.1038/s41598-023-35140-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185516/
https://www.ncbi.nlm.nih.gov/pubmed/37188744
http://dx.doi.org/10.1038/s41598-023-35140-5

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