Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma

Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 f...

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Detalles Bibliográficos
Autores principales: Jauhiainen, Maria K., Mohanraj, Ushanandini, Lehecka, Martin, Niemelä, Mika, Hirvonen, Timo P., Pratas, Diogo, Perdomo, Maria F., Söderlund-Venermo, Maria, Mäkitie, Antti A., Sinkkonen, Saku T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185587/
https://www.ncbi.nlm.nih.gov/pubmed/36857017
http://dx.doi.org/10.1007/s13365-023-01112-8
Descripción
Sumario:Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 formalin-fixed paraffin-embedded VS samples. Five samples were analyzed by targeted next-generation sequencing. Viral DNA was detected altogether in 24/46 (52%) tumor samples, mostly representing anelloviruses (46%). Our findings show frequent persistence of anelloviruses, considered normal virome, in VS. None of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13365-023-01112-8.

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