Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma

Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 f...

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Autores principales: Jauhiainen, Maria K., Mohanraj, Ushanandini, Lehecka, Martin, Niemelä, Mika, Hirvonen, Timo P., Pratas, Diogo, Perdomo, Maria F., Söderlund-Venermo, Maria, Mäkitie, Antti A., Sinkkonen, Saku T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185587/
https://www.ncbi.nlm.nih.gov/pubmed/36857017
http://dx.doi.org/10.1007/s13365-023-01112-8
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author Jauhiainen, Maria K.
Mohanraj, Ushanandini
Lehecka, Martin
Niemelä, Mika
Hirvonen, Timo P.
Pratas, Diogo
Perdomo, Maria F.
Söderlund-Venermo, Maria
Mäkitie, Antti A.
Sinkkonen, Saku T.
author_facet Jauhiainen, Maria K.
Mohanraj, Ushanandini
Lehecka, Martin
Niemelä, Mika
Hirvonen, Timo P.
Pratas, Diogo
Perdomo, Maria F.
Söderlund-Venermo, Maria
Mäkitie, Antti A.
Sinkkonen, Saku T.
author_sort Jauhiainen, Maria K.
collection PubMed
description Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 formalin-fixed paraffin-embedded VS samples. Five samples were analyzed by targeted next-generation sequencing. Viral DNA was detected altogether in 24/46 (52%) tumor samples, mostly representing anelloviruses (46%). Our findings show frequent persistence of anelloviruses, considered normal virome, in VS. None of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13365-023-01112-8.
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spelling pubmed-101855872023-05-17 Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma Jauhiainen, Maria K. Mohanraj, Ushanandini Lehecka, Martin Niemelä, Mika Hirvonen, Timo P. Pratas, Diogo Perdomo, Maria F. Söderlund-Venermo, Maria Mäkitie, Antti A. Sinkkonen, Saku T. J Neurovirol Short Communication Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 formalin-fixed paraffin-embedded VS samples. Five samples were analyzed by targeted next-generation sequencing. Viral DNA was detected altogether in 24/46 (52%) tumor samples, mostly representing anelloviruses (46%). Our findings show frequent persistence of anelloviruses, considered normal virome, in VS. None of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13365-023-01112-8. Springer International Publishing 2023-03-01 2023 /pmc/articles/PMC10185587/ /pubmed/36857017 http://dx.doi.org/10.1007/s13365-023-01112-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Jauhiainen, Maria K.
Mohanraj, Ushanandini
Lehecka, Martin
Niemelä, Mika
Hirvonen, Timo P.
Pratas, Diogo
Perdomo, Maria F.
Söderlund-Venermo, Maria
Mäkitie, Antti A.
Sinkkonen, Saku T.
Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma
title Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma
title_full Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma
title_fullStr Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma
title_full_unstemmed Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma
title_short Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma
title_sort herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185587/
https://www.ncbi.nlm.nih.gov/pubmed/36857017
http://dx.doi.org/10.1007/s13365-023-01112-8
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