Cargando…
iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
Recently, we reported that forkhead box A2 (FOXA2) is required for the development of human pancreatic α- and β-cells. However, whether miRNAs play a role in regulating pancreatic genes during pancreatic development in the absence of FOXA2 expression is largely unknown. Here, we aimed to capture the...
Autores principales: | Aldous, Noura, Elsayed, Ahmed K., Alajez, Nehad M., Abdelalim, Essam M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185633/ https://www.ncbi.nlm.nih.gov/pubmed/36749553 http://dx.doi.org/10.1007/s12015-023-10515-3 |
Ejemplares similares
-
Genome-wide differential expression profiling of long non-coding RNAs in FOXA2 knockout iPSC-derived pancreatic cells
por: Elsayed, Ahmed K., et al.
Publicado: (2023) -
Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency
por: Elsayed, Ahmed K., et al.
Publicado: (2021) -
Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
por: Aghadi, Maryam, et al.
Publicado: (2022) -
Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors
por: Islam, Zeyaul, et al.
Publicado: (2022) -
Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
por: Aldous, Noura, et al.
Publicado: (2023)