Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery

The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer...

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Detalles Bibliográficos
Autores principales: Zhang, Jiayu, Cai, Xiaomeng, Dou, Rui, Guo, Chen, Tang, Jiaruo, Hu, Yi, Chen, Hanqing, Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185705/
https://www.ncbi.nlm.nih.gov/pubmed/37200860
http://dx.doi.org/10.1016/j.omtn.2023.04.019
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author Zhang, Jiayu
Cai, Xiaomeng
Dou, Rui
Guo, Chen
Tang, Jiaruo
Hu, Yi
Chen, Hanqing
Chen, Jun
author_facet Zhang, Jiayu
Cai, Xiaomeng
Dou, Rui
Guo, Chen
Tang, Jiaruo
Hu, Yi
Chen, Hanqing
Chen, Jun
author_sort Zhang, Jiayu
collection PubMed
description The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs.
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spelling pubmed-101857052023-05-17 Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery Zhang, Jiayu Cai, Xiaomeng Dou, Rui Guo, Chen Tang, Jiaruo Hu, Yi Chen, Hanqing Chen, Jun Mol Ther Nucleic Acids Review The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs. American Society of Gene & Cell Therapy 2023-04-23 /pmc/articles/PMC10185705/ /pubmed/37200860 http://dx.doi.org/10.1016/j.omtn.2023.04.019 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhang, Jiayu
Cai, Xiaomeng
Dou, Rui
Guo, Chen
Tang, Jiaruo
Hu, Yi
Chen, Hanqing
Chen, Jun
Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
title Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
title_full Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
title_fullStr Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
title_full_unstemmed Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
title_short Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
title_sort poly(β-amino ester)s-based nanovehicles: structural regulation and gene delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185705/
https://www.ncbi.nlm.nih.gov/pubmed/37200860
http://dx.doi.org/10.1016/j.omtn.2023.04.019
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